PHYSIOLOGICAL EFFECTS OF DRUGS

This study tests if the drug Dimephosphon can improve recovery in people who have had an acute ischemic stroke (a stroke caused by a blood clot). The trial involves 184 adults aged 35-80 who will receive either Dimephosphon or a placebo within 24-72 hours of their stroke. The mai…

This study looks at whether using just one blood thinner (single antiplatelet therapy) is safer and as effective as using two (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a heart procedure with a drug-coated balloon. About 576 partici…

This study tests whether a sedative called dexmedetomidine can prevent long-term memory and thinking problems that often occur after heart surgery. About 2,400 adults aged 60 and older having bypass or valve surgery will receive either dexmedetomidine or a placebo during their op…

This study tests an injection called NT 201 (a type of botulinum toxin) to see if it safely reduces the appearance of prominent neck bands (platysma prominence) in adults. About 300 people with moderate to severe neck bands will receive either NT 201 or a placebo. The goal is to …

This study tests a new drug called (2R,6R)-HNK to see if it can quickly improve symptoms in people with major depression that hasn't responded to other treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with thei…

This study tests an injection called NT 201 (a type of botulinum toxin) against a placebo in 300 adults with moderate to severe neck band prominence. The goal is to see if it safely reduces the appearance of these bands. Participants will be followed for several weeks, and those …

This study aims to learn more about how depression, bipolar disorder, and suicide risk affect people and how treatments work. Researchers will follow 500 adults already receiving care at the NIH, using interviews, questionnaires, and optional tests like blood draws and brain scan…