DEPRESSIVE SYMPTOMS

This study tests whether a nasal spray containing esketamine and dexmedetomidine, given twice after childbirth, can lower the chance of postpartum depression in women who already had mild depressive symptoms during pregnancy. Esketamine is a fast-acting antidepressant, and dexmed…

This study tests a program called NPOWER365 for Black men who have sex with men and are living with HIV. The program uses a smartphone app, online forums, and resource referrals to help with medication adherence, mental health, and access to care. About 350 participants in the At…

This study explores whether routine blood vessel tests can help identify depression in people with chronic atrophic gastritis, a stomach condition. Many patients with this disease have undiagnosed depression due to stigma. Researchers will use ultrasound and other vascular measur…

This study tests whether trained youth mentors can deliver a brief therapy to reduce suicide risk in Hispanic adolescents aged 12-17. Participants will either receive 6 therapy sessions with a mentor or usual care. The goal is to see if this approach is feasible and helps reduce …

This study tests a community-based program to help Black and Hispanic teens aged 15-20 cope with chronic stress and prevent depression. Participants will join peer groups to learn skills and will be tracked for 2 years. The goal is to reduce depressive symptoms and improve physic…

This study tests whether replacing some regular gym classes with specialized physical education courses can prevent common health issues like nearsightedness, overweight, anxiety, and depression in junior high students. Two hundred students will be randomly assigned to either the…

This pilot study will test whether a mobile phone app can help reduce depression symptoms in African American adults. Eight participants will attend six weekly 90-minute classes through the app and complete surveys over four months. The goal is to see if this approach is effectiv…

This study tests whether baricitinib, an anti-inflammatory drug, can improve depression and cognitive symptoms in 30 male former football players aged 40-55 with at least 10 years of play. Participants take the drug every other week for 6 weeks, and researchers use brain scans an…

This study tests whether a smartphone app called MindfulCityU can help university students with mild depressive symptoms feel better. 120 students will either use the app for four weeks or join a waitlist. Researchers will measure changes in depression, anxiety, stress, and mindf…

This study tests whether mindfulness-based cognitive therapy (MBCT), adapted for Vietnamese culture, can reduce depression symptoms and improve quality of life. One hundred sixty adults with mild-to-moderate depression will be recruited from eight Buddhist pagodas near Hanoi. Hal…