Could a Two-Drug anesthesia combo lift Post-Surgery mood?
NCT ID NCT07753772
First seen Aug 10, 2026 · Last updated Aug 14, 2026 · Updated 3 times
Summary
This trial tests whether giving a combination of dexmedetomidine and esketamine during and after laparoscopic ureteral reconstruction can reduce depressive symptoms and anxiety in patients. The study enrolls 658 adults with ureteral stricture who are scheduled for this surgery. Participants are randomly assigned to receive the drug combo or a standard approach, and their mood is assessed using a questionnaire before discharge. The goal is to see if this low-dose combination can improve emotional recovery without increasing side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- A combination of two anesthetic drugs, dexmedetomidine and esketamine, given during and after surgery to potentially improve mood.
- What this could lead to
- If effective, this approach could offer a simple way to reduce post-surgical depression and anxiety in patients undergoing ureteral repair, improving recovery and quality of life.
- What could go wrong
- The trial is early and results may not apply to all surgeries. Both drugs have side effects, including low heart rate, low blood pressure, and psychiatric effects, which the study will monitor.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Peking University First Hospital
Beijing, Beijing Municipality, 100034, China
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