DEXMEDETOMIDINE

This large trial tests whether the sedative dexmedetomidine can prevent long-term memory and thinking problems that often follow heart surgery. Researchers will give the drug to 2,400 adults aged 60 and older during and after their operation, then track their cognitive function f…

This trial tests whether adding dexmedetomidine or magnesium sulphate to lidocaine for a peribulbar block (anesthesia around the eye) helps keep heart rate and blood pressure steady during dacryocystorhinostomy (tear duct surgery) under general anesthesia. Sixty adults undergoing…

This study compares different doses of two sedative drugs, propofol and dexmedetomidine, in children aged 1-12 undergoing MRI scans. The goal is to find the combination that provides adequate sedation with fewer side effects and faster recovery. Researchers will measure drug cons…

This study compares two medications, dexmedetomidine and lignocaine, given before placing a breathing tube in heart surgery patients. The goal is to see which drug better controls sudden rises in blood pressure and heart rate during the procedure. About 70 adults at risk for hear…

This study compares three sedation approaches—using dexmedetomidine, propofol, or both—during cataract surgery in 1,000 adults. Researchers will measure how well each method sedates patients, affects heart rate and blood pressure, and causes side effects like nausea. The goal is …

This study tests whether a nasal spray of dexmedetomidine can reduce agitation in children aged 3-6 after strabismus (eye muscle) surgery. 120 children will receive either 2 or 3 micrograms per kilogram of the medicine. The goal is to find the best dose to help children wake up c…

This study tests whether giving dexmedetomidine and esketamine during and after surgery can help patients recover better. 316 adults having general anesthesia will receive one or both drugs, and their recovery quality will be measured using a 15-item questionnaire. The goal is to…

This study tests whether a nose spray containing two drugs, dexmedetomidine and esketamine, can reduce pain after tonsil and adenoid surgery in children aged 3 to 7. About 160 kids will receive either the drug combo or a placebo spray right after anesthesia. Researchers will trac…

This study tests two different drug mixtures given as a nerve block to reduce pain after lower abdominal surgery. One mix uses bupivacaine with dexmedetomidine, the other uses bupivacaine with dexamethasone. The goal is to see which provides longer pain relief. About 60 adults ha…

This study tests whether wearing a virtual reality headset with calming scenes can reduce anxiety and stress during a cesarean section as well as a sedative drug called dexmedetomidine. Fifty-two women having planned C-sections will be randomly assigned to receive either the VR h…

This study tests two drugs—lidocaine and dexmedetomidine—given as infusions during laparoscopic sleeve gastrectomy to see which one helps with pain and recovery. Forty adults aged 20-50 with a BMI of 35-50 are being recruited. The goal is to find a better way to manage early post…

This study compares two spinal anesthesia recipes for people having a leg amputated above the knee due to sarcoma (a type of cancer). One group gets the standard fentanyl plus bupivacaine, the other gets an added drug called dexmedetomidine. The goal is to see if the combo delays…

This study tests a nasal spray combining two medicines (dexmedetomidine and esketamine) to help children aged 1-6 relax before surgery. The goal is to find the best dose that makes kids calm enough for a smooth start to anesthesia. About 80 children will take part to see how well…

This study tests whether adding a nasal spray drug called dexmedetomidine to the standard medication pregabalin can better relieve pain in people with fibromyalgia. The trial will enroll 400 adults with moderate to severe fibromyalgia who haven't found relief from non-drug treatm…

This study tests whether giving dexmedetomidine 20 minutes before anesthesia, instead of 10 minutes, better controls stress responses like high blood pressure and heart rate during breathing tube insertion. 45 adults undergoing surgery will be randomly assigned to one of three ti…