DEXMEDETOMIDINE

This study compared two sedative drugs—remimazolam and dexmedetomidine—to see which one better prevents postoperative delirium (sudden confusion) in patients aged 60 and older after thoracoscopic surgery. A total of 105 participants were randomly assigned to receive one of the tw…

This study looked at whether the drug dexmedetomidine, given during laparoscopic surgery for rectal or sigmoid colon cancer, can protect the lungs of patients aged 60 and older. The trial included 64 participants and measured oxygen levels and other breathing indicators. The goal…

This study tested whether adding dexmedetomidine to the standard drug mannitol can better control brain pressure during robotic prostate surgery. Sixty adults participated. The main goal was to measure changes in the optic nerve sheath, a marker of brain pressure. The study is co…

This study looked at whether adding dexmedetomidine to standard morphine pain relief after cancer surgery helps elderly patients (65-90 years) live longer. 1,500 participants were randomly assigned to receive either morphine alone or morphine plus dexmedetomidine for three days a…

This study tested whether giving a sedative called dexmedetomidine during a procedure to fix a brain aneurysm can prevent dangerous blood vessel spasms. 90 adults who had a brain bleed from a ruptured aneurysm took part. The goal was to see if the drug reduces complications and i…

This study tests whether combining two sedatives, dexmedetomidine and esketamine, can lower the chance of delirium (sudden confusion) in older patients (60+) after surgery in the ICU. Delirium is common and can lead to worse outcomes. The trial will involve 100 participants and t…

This study tested whether adding dexmedetomidine or dexamethasone to a local anesthetic mixture improves pain control and patient satisfaction during cataract surgery. 75 adults undergoing eye surgery received one of the two additives or a placebo. The main goal was to see how lo…

This study tested two methods of giving the drug dexmedetomidine to 70 adults during intubation (placing a breathing tube). One group received a slow infusion over 10 minutes, the other a quick bolus over 60 seconds. The goal was to see which method causes fewer changes in heart …

This study tested whether giving the sedative dexmedetomidine during lung surgery (without a breathing tube) can reduce coughing and pain. 144 adults took part. Researchers measured cough severity and the need for other painkillers. The goal is to make recovery smoother and more …

This study tested three sedation approaches for removing a Double-J ureteral stent, a common procedure. Sixty adults received either propofol alone, propofol plus dexmedetomidine, or propofol plus midazolam. Researchers measured total propofol use and sedation levels to find the …

This study tested three different sedatives given as a mist to children aged 3-7 before they had their tonsils and adenoids removed. The goal was to see which drug helped kids stay calm and separate easily from their parents. Sixty children were randomly assigned to receive eithe…

This study tested whether giving a low-dose sedative called dexmedetomidine at night can prevent delirium (sudden confusion) in older adults after heart surgery. The trial involved 504 patients aged 60-89 who had heart surgery with a heart-lung machine. The drug was infused overn…

This study tested a new epidural pain relief combination (dexmedetomidine, esketamine, and ropivacaine) against the standard mix (sufentanil and ropivacaine) in 300 women during labor. The goal was to see if the new combo works as well for pain and is safer for newborns. It's a p…

This study looked at 93 adults having bladder tumor surgery under spinal anesthesia. It compared two intravenous drugs—magnesium sulfate and dexmedetomidine—to see which better controlled pain after surgery. Magnesium sulfate led to lower pain scores, delayed the need for extra p…

This study looked at 60 children aged 3-8 years who needed a procedure to close a hole in their heart. Researchers compared general anesthesia to a lighter sedation combined with numbing medicine at the catheter site. They measured heart rate and blood pressure to see which appro…

This completed Phase 4 trial tested two different doses (5 mcg vs 10 mcg) of dexmedetomidine added to standard spinal anesthesia for women having planned C-sections. The goal was to see which dose provides longer pain relief and muscle relaxation. Sixty women aged 20-40 participa…

This study looked at whether adding dexmedetomidine to standard morphine pain relief after cancer surgery could lower the chance of delirium (sudden confusion) in patients aged 65 and older. A total of 1500 participants were randomly assigned to receive either morphine alone or m…

This study tested whether giving a medicated mist (dexmedetomidine) before surgery could prevent dangerous spikes in heart rate and blood pressure when placing a breathing tube in 90 obese patients undergoing laparoscopic bariatric surgery. The approach aims to make the procedure…

This study tested whether giving a combination of two sedative drugs (dexmedetomidine and esketamine) at night can improve sleep quality for ICU patients who need a breathing tube or high-flow oxygen mask. The trial involved 174 adults aged 50 and older after surgery. Researchers…

This study tested whether adding dexmedetomidine to a standard local anesthetic (bupivacaine) in a nerve block after C-section can improve pain relief. 80 women having planned C-sections took part. The goal was to see if the combination extends pain-free time, reduces recovery ti…

This study tested two drugs, dexmedetomidine and lidocaine, given during surgery to control pain after a mastectomy. 40 women took part. The goal was to see which drug delays the need for extra pain medicine and keeps vital signs stable.

This completed study looked at whether the sedative dexmedetomidine can protect blood vessel lining during rhinoplasty. 90 patients received either standard anesthesia or dexmedetomidine plus anesthesia. Researchers measured two blood markers of vessel damage to see if dexmedetom…

This study compared two types of anesthesia for major spine surgery to see which one better preserves the nerve signals doctors monitor during the operation. 78 adults aged 21-45 undergoing spine surgery received either a standard drug combination or one with an added sedative ca…

This study looked at 142 people with hard-to-treat high blood pressure who had a procedure called renal denervation, which uses energy to calm overactive kidney nerves. Researchers compared two types of sedation—dexmedetomidine versus a fentanyl-propofol combination—to see which …

This study tested whether dexmedetomidine, a sedative often used during surgery, changes how quickly the stomach empties in people having their gallbladder removed. Researchers used ultrasound to measure stomach volume in 80 patients before and after surgery. The goal was to see …