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Can a sedative shield elderly lungs during cancer surgery?

NCT ID NCT07385898

Disease control Sponsor: The Second Affiliated Hospital of Chongqing Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether the drug dexmedetomidine, given during laparoscopic surgery for rectal or sigmoid colon cancer, can protect the lungs of patients aged 60 and older. The trial included 64 participants and measured oxygen levels and other breathing indicators. The goal is to see if this drug can reduce lung complications after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Dexmedetomidine
What this could lead to
If it works, this could point toward a way to reduce lung complications in elderly patients after laparoscopic colorectal surgery.
What could go wrong
This is a small, completed trial with only 64 participants. The results may not apply to all patients, and the drug may not show clear benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

64 people

The number who actually took part.

Started

Apr 2023

Finished

Feb 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients undergoing elective laparoscopic surgery for rectal or sigmoid colon cancer. 2. American Society of Anesthesiologists (ASA) physical status classification I-III. 3. Age ≥60 years and \<85 years. 4. Voluntary participation and ability to understand and sign the informed consent form. Exclusion Criteria: 1. Patients with obesity (BMI\>28 kg/m2) 2. Grade 3 hypertensive patients (systolic blood pressure ≥180 mmHg and/or diastolic blood pressure ≥110 mmHg) 3. Patients with acute coronary syndrome, sinus bradycardia (heart rate \<45 beats/minute), II or III degree atrioventricular block, or NYHA heart failure class III or IV 4. Patients with a history of severe chronic obstructive pulmonary disease (COPD) (GOLD stage III or IV), severe or uncontrolled bronchial asthma, lung infections, bronchiectasis, thoracic deformities, and chest diseases (such as mediastinal tumors and thoracic tumors) 5. Pulmonary artery pressure ≥ 60 mmHg 6. Patients with Child-Pugh Class B or C liver function 7. Patients with stage 4 or 5 chronic kidney disease 8. Patients with hyperthyroidism, pheochromocytoma 9. Patients with hearing, intellectual, communication, or cognitive impairments 10. Patients who cannot cooperate with the study for any reason, or whom the investigator deems unsuitable for inclusion in this trial.

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Conditions

The condition(s) this trial relates to.

acute lung injury Lung Injury rectal cancer rectal neoplasm sigmoid colon cancer sigmoid neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dexmedetomidine Lung injury Rectal tumors Surgery, laparoscopic Tumor of sigmoid colon

Contacts and locations

Locations

  • The Second Affiliated Hospital of Chongqing Medical University

    Chongqing, Chongqing Municipality, 400000, China

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