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Can a nasal spray calm nerves before brain surgery?

NCT ID NCT07801014

Symptom relief Sponsor: Beijing Tiantan Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time

Summary

Researchers are testing whether a dexmedetomidine nasal spray can reduce anxiety in patients scheduled for brain tumor surgery. Participants receive the spray the night before and the morning of surgery, and their anxiety levels are measured before and after the procedure. The trial includes 114 adults with elevated preoperative anxiety who are undergoing elective supratentorial tumor resection.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexmedetomidine nasal spray
What this could lead to
If it works, this could offer a simple, non-invasive way to reduce anxiety before brain surgery, improving patient comfort and recovery.
What could go wrong
This is an early, single-center trial with 114 patients, so results may not apply broadly. The drug can cause low heart rate or sedation, and its benefit over standard care is unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 114 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * American Society of Anesthesiologists physical status I to III * Scheduled to undergo elective supratentorial tumor resection * Preoperative STAI-S score \>45 * Obtain written informed consent Exclusion Criteria: * Severe hepatic or renal insufficiency * Allergy to dexmedetomidine or its excipients * Severe bradycardia (heart rate \<50 bpm), sick sinus syndrome, or second-/third-degree AV block without pacemaker * Use of α2-agonists, benzodiazepines, or other sedatives/analgesics within 24 hours preoperatively * History of alcohol, drug, or psychoactive substance dependence * Diagnosed or suspected obstructive sleep apnea syndrome * Nasal anatomical abnormalities, acute rhinitis, epistaxis, or other nasal conditions affecting drug administration * Pregnancy or lactation * Communication barriers, psychiatric disorders, or cognitive impairment precluding scale completion * Visual/hearing impairment or inability to read

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Conditions

The condition(s) this trial relates to.

anxiety anxiety disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anxiety Dexmedetomidine

How to take part

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  1. The places running it

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  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Beijing Tian Tan Hospital, Capital Medical University

    Beijing, Beijing Municipality, 100070, China

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