Nighttime drug cocktail aims to help seniors sleep better after joint surgery
NCT ID NCT05950646
First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time
Summary
This trial tests whether a very low dose of two drugs—dexmedetomidine and esketamine—given at night can improve sleep quality in older adults (65-89 years) undergoing knee or hip replacement. Poor sleep after surgery is common and linked to worse recovery. The study compares the drug combination to a placebo, measuring sleep quality through questionnaires and wearable monitors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Dexmedetomidine and Esketamine
- What this could lead to
- If effective, this could offer a simple way to improve sleep and recovery for older patients after joint replacement surgery.
- What could go wrong
- This is a small, early-phase trial, and the drugs may not improve sleep or could cause side effects like low blood pressure or nausea.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Beijing Hospital
Beijing, Beijing Municipality, 100005, China
-
Peking University First Hospital
Beijing, Beijing Municipality, 100034, China
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