DEXMEDETOMIDINE

This study tests whether a sedative called dexmedetomidine can prevent long-term memory and thinking problems that often occur after heart surgery. About 2,400 adults aged 60 and older having bypass or valve surgery will receive either dexmedetomidine or a placebo during their op…

This study tests a nasal spray combining two medicines (dexmedetomidine and esketamine) to help children aged 1-6 relax before surgery. The goal is to find the best dose that makes kids calm enough for a smooth start to anesthesia. 80 children will participate, and researchers wi…

This study compares pregabalin alone versus pregabalin plus dexmedetomidine for treating fibromyalgia, a condition causing widespread pain and fatigue. Researchers want to see if the combination provides better pain relief without more side effects. The study will enroll 400 adul…

This study tests whether a nasal spray containing two medicines (dexmedetomidine and esketamine) can safely reduce pain in children aged 3-7 after tonsil and adenoid surgery. About 160 children will receive either the spray or a placebo, and their pain levels will be tracked for …

This study tests whether lidocaine or dexmedetomidine works better to control pain and improve recovery in 40 adults having laparoscopic sleeve gastrectomy (weight-loss surgery). Both drugs are given through a vein during surgery. The goal is to see which one reduces pain, delays…

This study tests whether giving dexmedetomidine and esketamine during and after surgery helps patients feel better and recover faster. About 316 adults having surgery under general anesthesia will take part. The goal is to see if these drugs improve pain, comfort, and emotional w…

This study compares three sedation methods (dexmedetomidine, propofol, or both) in 1,000 adults having cataract surgery. The goal is to see which approach provides the best sedation with the fewest side effects like low blood pressure or nausea. All participants will also receive…

This study tests whether a nasal spray of dexmedetomidine, a sedative, can reduce confusion and agitation in children aged 3-6 after strabismus (eye muscle) surgery. Researchers will compare two different doses (2 vs 3 mcg/kg) in 120 children to find the most effective dose. The …

This study compares two pain relief methods during spinal anesthesia for above-knee amputation in people with sarcoma of the lower leg. One group gets a standard drug (fentanyl) plus an extra drug (dexmedetomidine), while the other gets fentanyl alone. The goal is to see if the c…

This study tests whether using virtual reality (VR) goggles or a sedative drug called dexmedetomidine is better at reducing anxiety and stress in women having a planned cesarean section. About 52 mothers will be randomly assigned to one of the two methods. The goal is to find a s…

This study tests whether combining two sedatives (dexmedetomidine and esketamine) can lower the risk of delirium—sudden confusion—in older patients (60+) after surgery in the ICU. Delirium can lead to worse outcomes, and each drug alone has side effects. The trial will involve 10…

This study tests whether giving a single dose of dexmedetomidine, a calming medication, at different times before surgery can lower the body's stress response when a breathing tube is placed. About 45 adults having surgery will be randomly assigned to receive the drug at differen…

This study tests two different drug mixtures given as a nerve block to control pain after lower abdominal surgery. The goal is to see which combination provides longer pain relief. Sixty adults having lower abdominal surgery will take part.