DEXMEDETOMIDINE

This study tests if giving a nose spray of dexmedetomidine before a heart procedure (PCI) can reduce heart injury or heart attack. About 1800 adults will receive either the drug or a placebo spray. Researchers will check blood markers and track heart events for 30 days to see if …

This study looks at whether giving older adults (65-90) a combination of two medicines (dexmedetomidine and esketamine) along with a gentle brain stimulation technique (tDCS) during and after surgery can prevent long-term memory and thinking problems. The researchers will follow …

This study tests whether giving older adults (65-90 years) a combination of two medicines (dexmedetomidine and esketamine) along with a gentle brain stimulation technique (tDCS) before and after surgery can prevent confusion and memory problems. About 1,160 participants will be f…

This study looks at whether giving dexamethasone, dexmedetomidine, or both can help the gut work normally again after laparoscopic gallbladder removal. About 160 adults having this surgery will receive one of these drugs or a placebo right after anesthesia. The main goal is to se…

This study tests whether giving a combination of two medicines (dexmedetomidine and esketamine) before and after spinal surgery can lower the chance of long-term pain. About 274 adults aged 40 to 79 having spine surgery will take part. The goal is to see if this drug combo works …

This study looks at different combinations of two sedative medicines, propofol and dexmedetomidine, to find the best way to sedate children aged 1 to 12 for MRI scans. The goal is to use less propofol, which may have risks, while keeping children comfortable and not slowing their…

This study tests whether giving a combination of two drugs (dexmedetomidine and esketamine) during and after spinal surgery can lower the chance of moderate-to-severe pain in the first three days after the operation. About 274 adults aged 40 to 79 having spine surgery will take p…

This study tests adding two drugs, dexmedetomidine or clonidine, to standard spinal anesthesia for women having a C-section. The goal is to reduce uncomfortable pulling, tugging, or pressure during surgery and improve pain relief after. About 150 pregnant women will take part, an…

This study looks at whether avoiding opioids during heart bypass surgery helps elderly patients recover faster. Sixty people aged 65 and older will receive either opioid-free or standard opioid anesthesia. The goal is to see if the opioid-free approach leads to earlier breathing …

This study tests whether a nasal spray containing dexmedetomidine can safely sedate adults before surgery when little monitoring is available. About 564 participants will receive either the spray or a placebo 45 minutes before anesthesia. Researchers will track breathing and hear…

This study tests whether a combination of two sedative drugs, esketamine and dexmedetomidine, can safely and effectively reduce the time ICU patients spend in a state of severe confusion and agitation (hyperactive delirium) while they are on non-invasive breathing support. About …