DEXMEDETOMIDINE

This study tests whether a nasal spray containing esketamine and dexmedetomidine, given twice after childbirth, can lower the chance of postpartum depression in women who already had mild depressive symptoms during pregnancy. Esketamine is a fast-acting antidepressant, and dexmed…

This study tests whether a medicine given as a nose spray before a heart stent procedure can reduce heart muscle injury or heart attack. About 1800 adults scheduled for elective stent placement will receive either the medicine or a placebo spray. Researchers will measure heart da…

This long-term study follows older adults (65-90) who are having non-cardiac surgery to see if a combination of two drugs (dexmedetomidine and esketamine) plus a gentle brain stimulation technique (tDCS) can prevent memory and thinking problems that sometimes occur after surgery.…

This study tests two approaches—a combination of medicines (dexmedetomidine and esketamine) and a gentle brain stimulation technique (tDCS)—to prevent confusion and memory problems after surgery in older adults. About 1,160 patients aged 65-90 with mild cognitive issues will be e…

This study tests whether a combination of two sedatives, esketamine and dexmedetomidine, can better control agitation and shorten delirium in intensive care unit (ICU) patients who are on non-invasive breathing support. The trial will enroll 388 adults with hyperactive delirium a…

This study tests whether a nasal spray containing two medicines, dexmedetomidine and esketamine, can improve sleep quality and thinking abilities in older adults with mild-to-moderate Alzheimer's-related cognitive impairment and sleep problems. Sixty participants will receive eit…

This study will test whether adding dexmedetomidine or clonidine to standard spinal anesthesia can reduce uncomfortable pulling, tugging, and pressure sensations during cesarean delivery. About 150 pregnant women having a C-section will be randomly assigned to receive one of the …

This study tests whether giving a combination of two drugs, dexmedetomidine and esketamine, during and after spinal surgery can reduce moderate-to-severe pain in the first three days after the operation. About 274 adults aged 40 to 80 having spine surgery will be randomly assigne…

This study tests whether giving a combination of two drugs (dexmedetomidine and esketamine) before and after spine surgery can lower the risk of long-term pain. About 274 adults aged 40-79 having spine surgery will take part. The goal is to see if this approach reduces pain that …

This study tests whether avoiding opioids during heart bypass surgery helps elderly patients recover faster. Sixty patients aged 65 and older will receive either opioid-free anesthesia with dexmedetomidine and ketamine or standard opioid-based anesthesia. The goal is to see if th…

This study will test whether giving dexamethasone, dexmedetomidine, or both right after gallbladder surgery helps the gut start working again sooner. 160 adults having laparoscopic gallbladder removal will be randomly assigned to one of four groups, including a placebo. The main …

This study tests a nasal spray containing dexmedetomidine to help patients relax before surgery, even with minimal monitoring. Researchers will compare it to a placebo in 564 adults to see if it causes fewer breathing or heart problems. The goal is to find a safer, easier way to …