Could a nasal spray boost sleep and brain health in seniors?
NCT ID NCT07610343
First seen May 28, 2026 · Last updated Jun 23, 2026 · Updated 6 times
Summary
This study tests whether a nasal spray containing two medicines, dexmedetomidine and esketamine, can improve sleep quality and thinking abilities in older adults with mild-to-moderate Alzheimer's-related cognitive impairment and sleep problems. Sixty participants will receive either the active spray or a placebo twice a week for four weeks. The main goal is to see if sleep quality gets better, with a secondary look at whether thinking skills also improve.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Peking University First Hospital
Beijing, Beijing Municipality, 100034, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
dexmedetomidine and esketamine nasal spray
What this could lead to
If it works, this could point toward a new way to improve sleep and possibly slow cognitive decline in older adults with Alzheimer's disease.
What could go wrong
This is a small, early-phase trial with only 60 participants. The combination may cause side effects like low blood pressure, slow heart rate, or neuropsychiatric issues, and it may not improve sleep or cognition as hoped.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.