Could a nasal spray boost sleep and brain health in seniors?

This study tests whether a nasal spray containing two medicines, dexmedetomidine and esketamine, can improve sleep quality and thinking abilities in older adults with mild-to-moderate Alzheimer's-related cognitive impairment and sleep problems. Sixty participants will receive either the active spray or a placebo twice a week for four weeks. The main goal is to see if sleep quality gets better, with a secondary look at whether thinking skills also improve.