New study aims to shield aging brains from Surgery's mental fog

NCT ID NCT07576543

Not yet recruiting Prevention Sponsor: Peking University First Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This long-term study follows older adults (65-90) who are having non-cardiac surgery to see if a combination of two drugs (dexmedetomidine and esketamine) plus a gentle brain stimulation technique (tDCS) can prevent memory and thinking problems that sometimes occur after surgery. The study will track participants for 3 months and beyond, looking at cognitive function and overall health. It aims to find a way to protect the brains of older patients during and after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dexmedetomidine-esketamine combination and transcranial direct current stimulation (tDCS)
What this could lead to: If successful, this could point toward a way to prevent long-term cognitive decline in older adults after surgery, improving their quality of life.
What could go wrong: This is a follow-up of an ongoing trial, so results are not yet available. The interventions may not show benefit, and individual responses can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COGNITIVE FUNCTION DEXMEDETOMIDINE ESKETAMINE OLDER PATIENTS SURGERY SURVIVAL TRANSCRANIAL DIRECT CURRENT STIMULATION

Contacts and locations

Locations

First Affilited Hospital, School of Medicine, Zhejiang University

Hangzhou, Zhejiang, 310006, China
Fujian Medical University Union Hospital

Fuzhou, Fujian, 362011, China
Peking University First Hospital

Beijing, Beijing Municipality, 100034, China
Peking University Shenzhen Hospital

Shenzhen, Guangdong, 518036, China
Second Affilited Hospital, School of Medicine, Zhejiang University

Hangzhou, Zhejiang, 310009, China
Xijing Hospital, Air Force Medical University

Xi'an, Shaanxi, 710032, China

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