New study aims to shield aging brains from Surgery's mental fog
NCT ID NCT07576543
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This long-term study follows older adults (65-90) who are having non-cardiac surgery to see if a combination of two drugs (dexmedetomidine and esketamine) plus a gentle brain stimulation technique (tDCS) can prevent memory and thinking problems that sometimes occur after surgery. The study will track participants for 3 months and beyond, looking at cognitive function and overall health. It aims to find a way to protect the brains of older patients during and after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Dexmedetomidine-esketamine combination and transcranial direct current stimulation (tDCS)
What this could lead to
If successful, this could point toward a way to prevent long-term cognitive decline in older adults after surgery, improving their quality of life.
What could go wrong
This is a follow-up of an ongoing trial, so results are not yet available. The interventions may not show benefit, and individual responses can vary.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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First Affilited Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, 310006, China
Contact Email: •••••@•••••
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Fujian Medical University Union Hospital
Fuzhou, Fujian, 362011, China
Contact Email: •••••@•••••
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Peking University First Hospital
Beijing, Beijing Municipality, 100034, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Peking University Shenzhen Hospital
Shenzhen, Guangdong, 518036, China
Contact Email: •••••@•••••
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Second Affilited Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, 310009, China
Contact Email: •••••@•••••
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Xijing Hospital, Air Force Medical University
Xi'an, Shaanxi, 710032, China
Contact Email: •••••@•••••