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Drug combo may cut opioid use after lung surgery

NCT ID NCT06837519

Symptom relief Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This trial tests whether giving lidocaine, dexmedetomidine, or both during video-assisted thoracoscopic surgery (VATS) can reduce pain and the need for morphine afterward. Adults undergoing VATS under general anesthesia will receive one of the two drugs or a combination. The main goal is to see how much morphine patients need after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
lidocaine and dexmedetomidine infusions, alone or combined
What this could lead to
If successful, this combination could offer better pain control and reduce the need for morphine after lung surgery.
What could go wrong
This is a small, early-phase trial, so results may not apply broadly. Both drugs can cause side effects like low blood pressure or slow heart rate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

75 people

The number who actually took part.

Started

Feb 2025

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years old. * Both sexes. * American Society of Anesthesiologists (ASA) physical status of I, II. * Patients undergoing video-assisted thoracoscopic surgery (VATS) under general anesthesia. Exclusion Criteria: * Hypersensitivity to any of the used drugs. * Coagulation disorder. * Body mass index \>35 kg/m2. * History of chronic pain requiring daily opioids/steroids/clonidine/other α2 agonist/analgesics or any drugs acting on the central nervous system during the previous 2 weeks, and drug/alcohol abuse. * Contraindication to the use of local anesthetics. * Cardiovascular disease. * Severe respiratory, renal or hepatic impairment. * Insulin-dependent diabetes mellitus. * Central nervous system or psychiatric disease.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dexmedetomidine Infusion Lidocaine Perioperative pain Video-assisted thoracoscopic surgery

Contacts and locations

Locations

  • Ain Shams University

    Cairo, 11591, Egypt

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