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Can a simple wash of local anesthetic cut Post-Surgery pain and opioid use?

NCT ID NCT07775599

Symptom relief Sponsor: Misr University for Science and Technology Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time

Summary

This trial tests whether placing lidocaine and bupivacaine—two common local anesthetics—inside the abdomen and at incision sites during laparoscopic surgery can reduce pain right after the operation. Adults aged 18 to 60 scheduled for procedures like gallbladder removal or hernia repair will receive either the anesthetic solution or a saltwater placebo during surgery. Researchers will measure pain scores, the need for extra painkillers, and how long patients stay in the hospital to see if this approach improves recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Lidocaine and bupivacaine, local anesthetics, given as a liquid instilled into the abdomen and at incision sites during surgery
What this could lead to
If effective, this approach could offer a simple, drug-free way to ease pain right after laparoscopic surgery, reducing the need for opioid painkillers and shortening hospital stays.
What could go wrong
This is a small, early-stage trial, and the benefit may be modest or not appear at all. Local anesthetics carry rare risks like allergic reactions or effects on the heart, and results may not apply to all surgeries.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

64 people

The number who actually took part.

Started

Aug 2025

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 to 60 years. * Scheduled for laparoscopic abdominal surgery (e.g., laparoscopic cholecystectomy, laparoscopic appendectomy, or laparoscopic hernia repair). * American Society of Anesthesiologists (ASA) physical status I or II. * No history of chronic pain, opioid dependence, or severe medical comorbidities. * Able and willing to provide written informed consent. Exclusion Criteria: * Conversion from laparoscopic to open surgery. * Acute cholecystitis, gangrene, or empyema of the gallbladder. * Oncologic or extensive laparoscopic procedures expected to have a prolonged operative time. * Known allergy or hypersensitivity to lidocaine, bupivacaine, or other local anesthetic agents. * Diabetes mellitus. * Current systemic corticosteroid use. * Pregnancy. * Cardiac, pulmonary, hepatic, or renal disorders. * History of opioid use or opioid dependence.

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Conditions

The condition(s) this trial relates to.

Pain Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Abdominal laparoscopic and/or robotic surgery Bupivacaine Lidocaine Local anasthesia Post operative pain, acute

Contacts and locations

Locations

  • The Memorial Souad Kafafi University Hospital

    Giza, Egypt

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