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Could a steroid injection double as a painkiller for brain surgery?

NCT ID NCT07788261

Symptom relief Sponsor: Assiut University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 26, 2026 · Last updated Aug 27, 2026 · Updated 1 time

Summary

This trial asks whether adding a steroid called dexamethasone to a local anesthetic (lidocaine) can improve pain relief after brain surgery (craniotomy). About 100 adults scheduled for this surgery will receive either the steroid-anesthetic mix or the standard anesthetic with epinephrine, injected into the scalp before the incision. Researchers will measure pain scores, opioid use, and vital signs to see if the combination offers better, longer-lasting pain control.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A combination of dexamethasone (a steroid) and lidocaine (a local anesthetic) injected into the scalp before surgery
What this could lead to
If it works, this could point toward a better way to manage pain after brain surgery, potentially reducing the need for opioids.
What could go wrong
This is a small, early-stage trial, and the benefit may be modest or not appear at all. There are also risks like infection or allergic reactions, though rare.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

100 people

The number who actually took part.

Started

Dec 2024

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients age between 20 and 60 years. * Both sexes. * American Society of Anesthesiologists (ASA) physical status I and II * Scheduled for elective supratentorial tumor craniotomy under general anesthesia. Exclusion Criteria: * Patients with known hypersensitivity to lidocaine or dexamethasone. * Chronic corticosteroid therapy. * Pre-existing coagulopathy. * Significant hepatic or renal impairment.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Craniotomy Dexamethasone Lidocaine Scalp incision infiltration

Contacts and locations

Locations

  • Assiut University

    Asyut, Asyut Governorate, 71515, Egypt

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