Can a new patch safely protect the brain after surgery?

NCT ID NCT07758790

Not yet recruiting Disease control Sponsor: DePuy Synthes Products, Inc. Source: ClinicalTrials.gov ↗

First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time

Summary

This registry study is evaluating the safety and performance of SYNTHECEL, a device used to close and protect the dura—the outer covering of the brain—during cranial surgery. Researchers will follow about 112 participants who undergo craniotomy or craniectomy and receive SYNTHECEL as part of their procedure. The study will track outcomes such as cerebrospinal fluid leakage, adhesion formation, and neurological status to see how well the device works in real-world clinical settings.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: SYNTHECEL, a device used to close and protect the outer covering of the brain during cranial surgery
What this could lead to: If successful, this registry could provide real-world evidence on the safety and performance of SYNTHECEL, potentially supporting its broader use in routine cranial surgeries.
What could go wrong: This is an observational registry, not a controlled trial, so it cannot prove cause and effect. Results may be influenced by variations in surgical practice and patient populations.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CRANIOTOMY

Contacts and locations

Locations

Baylor College of Medicine

Houston, Texas, 77030, United States
Cleveland Clinic

Weston, Florida, 33331 3609, United States
Kettering Medical Center

Kettering, Ohio, 45429, United States
University of Kentucky

Lexington, Kentucky, 40536, United States

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