Brain training may ward off depression in vulnerable teens

NCT ID NCT04346784

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This study tests whether computer-based training that targets emotional memory or attention can prevent major depression in young people who have depressive symptoms or have recovered from a depressive episode. Participants are randomly assigned to one of three active training programs or a placebo, completing daily sessions for two weeks, with a booster at six months. They are followed for five years to see if they develop a major depressive episode and to identify cognitive factors that predict depression onset.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Computer-based emotional working memory training (positive or negative) or attention bias training
What this could lead to
If effective, this could offer a non-drug, brain-training approach to prevent major depression in young people at risk.
What could go wrong
The training is brief and the trial is relatively small, so effects may be modest or not last. It is also unclear if results will apply to all youth.

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Conditions

The condition(s) this trial relates to.

Depression Emotional Regulation major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Department of Psychology, Hunan Normal University

    Changsha, Hunan, 400081, China

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