Brain training may ward off depression in vulnerable teens
NCT ID NCT04346784
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This study tests whether computer-based training that targets emotional memory or attention can prevent major depression in young people who have depressive symptoms or have recovered from a depressive episode. Participants are randomly assigned to one of three active training programs or a placebo, completing daily sessions for two weeks, with a booster at six months. They are followed for five years to see if they develop a major depressive episode and to identify cognitive factors that predict depression onset.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Computer-based emotional working memory training (positive or negative) or attention bias training
- What this could lead to
- If effective, this could offer a non-drug, brain-training approach to prevent major depression in young people at risk.
- What could go wrong
- The training is brief and the trial is relatively small, so effects may be modest or not last. It is also unclear if results will apply to all youth.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department of Psychology, Hunan Normal University
Changsha, Hunan, 400081, China
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