Lifestyle makeover may shield aging brains from Depression-Linked decline
NCT ID NCT07009223
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing whether lifestyle changes—like following a Mediterranean diet, exercising regularly, or doing cognitive training—can prevent cognitive decline and improve mood in people aged 50 to 80 who have depressive symptoms or major depression but no current memory problems. Researchers will compare three groups over 12 weeks, measuring changes in depression, quality of life, and thinking skills. They will also look at how these changes affect gut bacteria and inflammation.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Mediterranean diet, physical activity, and cognitive training
What this could lead to
If successful, this could show that simple lifestyle changes like diet and exercise help protect memory and thinking skills in older adults with depression.
What could go wrong
This is a small, early-stage study (120 people) testing multiple interventions, so results may not apply broadly. It also relies on participants sticking to the programs, which can be challenging.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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IRCCS Centro San Giovanni di Dio Fatebenefratelli
RECRUITINGBrescia, 25125, Italy
Contact Email: •••••@•••••