Magnetic pulses to the brain may lift depression after concussion

NCT ID NCT05426967

Recruiting now Symptom relief Sponsor: Henry M. Jackson Foundation for the Advancement of Military Medicine Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether a non-invasive procedure called repetitive transcranial magnetic stimulation (rTMS) can safely reduce depressive symptoms in U.S. military service members and veterans who have had a concussion or mild traumatic brain injury. About 198 participants will receive either active rTMS or a sham (fake) treatment to compare effects. The goal is to find a better way to treat depression in this group without medication.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: repetitive transcranial magnetic stimulation (rTMS)
What this could lead to: If it works, this could offer a non-drug treatment option for depression after concussion, potentially improving quality of life for military members and veterans.
What could go wrong: This is an early adaptive trial with no phase designation, so results are uncertain. The sham group may also show improvement, and long-term benefits are not yet known.

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Conditions

The condition(s) this trial relates to.

Brain Concussion Depression traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONCUSSION DEPRESSIVE SYMPTOMS MILD TRAUMATIC BRAIN INJURY

Contacts and locations

Locations

Alexander T. Augusta Military Medical Center
RECRUITING

Fort Belvoir, Virginia, 22060, United States
VA Palo Alto Health Care System
RECRUITING

Palo Alto, California, 94304, United States
William Beaumont Army Medical Center
RECRUITING

Fort Bliss, Texas, 79918, United States

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