Sound waves aim to quiet fibromyalgia pain

NCT ID NCT07226648

Recruiting now Symptom relief Sponsor: SPIRE Therapeutics Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 14, 2026 · Updated 4 times

Summary

This study tests whether a noninvasive ultrasound device can reduce pain in people with fibromyalgia. 180 adults will receive either real or sham ultrasound to a brain area linked to pain, over four sessions in one month. Researchers will track pain scores and symptom impact for 16 weeks to see if the treatment works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Focused ultrasound (DIADEM device)
What this could lead to: If it works, this could offer a new, noninvasive way to ease fibromyalgia pain without drugs or surgery.
What could go wrong: This is an early-stage trial with no phase designation, so results may not confirm effectiveness. The treatment is temporary (4 sessions) and may not provide lasting relief.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

fibromyalgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FIBROMYALGIA

Contacts and locations

Locations

Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Northwell Health - The Feinstein Institutes of Clinical Research
RECRUITING

Manhasset, New York, 10030, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Minnesota Medical Center Fairview
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84108, United States
WVU Rockefeller Neuroscience Institute
RECRUITING

Morgantown, West Virginia, 26505, United States
Washington University in St. Louis
RECRUITING

St Louis, Missouri, 63110, United States

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