FIBROMYALGIA

This study looks at whether adding shiatsu—a type of gentle bodywork—to usual medical care can improve quality of life for children and teens (ages 10-18) with chronic pain that is not caused by inflammation. About 40 participants will receive one 30-minute shiatsu session each w…

This study tests a new non-drug approach for fibromyalgia that combines cognitive training with acupuncture. Researchers want to see if this helps the brains of patients and clinicians work in sync, which may improve pain relief. About 100 adults with fibromyalgia will take part.…

This study tests whether energy healing can reduce pain and change brain activity in women with fibromyalgia. Twenty-five participants will receive either real or sham energy healing while their brains are scanned with fMRI. The goal is to see if real energy healing improves pain…

This study looks at whether a walking program that combines outdoor walks, treadmill use, and a mobile app can improve heart and lung function and quality of life in women with fibromyalgia. About 54 women aged 25-55 who haven't exercised regularly will take part. The goal is to …

This study is for adults with fibromyalgia whose pain hasn't been helped enough by standard treatments. Researchers want to see if adding esketamine (a rapid-acting painkiller) to usual care can provide better and faster pain relief. About 92 participants will be randomly assigne…

This study tests whether low, non-hallucinogenic doses of psilocybin (5 mg or 10 mg) can reduce pain in 35 adults with fibromyalgia. Participants will receive both placebo and psilocybin in random order and complete pain tests. The goal is to see if this psychedelic compound can …

This study compares two medications, pregabalin and mirogabalin, to see which works better for easing pain in people with fibromyalgia, a condition causing widespread pain and fatigue. About 674 adults with moderate to severe fibromyalgia who haven't tried these drugs before will…

This study looks at whether a program that combines counseling and museum visits can help people with fibromyalgia, a condition causing widespread pain and emotional distress. Researchers will first assess participants' mental and physical health, then offer a therapy that includ…

This study looks at whether personalized physical training and a type of nerve stimulation can help reduce pain, improve sleep, and ease fatigue in people with fibromyalgia. About 75 adults with fibromyalgia and chronic fatigue will be split into three groups: one gets exercise p…

This study tests whether an 8-week program combining art, mindfulness, and body awareness in a university museum can reduce pain and improve quality of life for women with fibromyalgia. About 44 women will be randomly assigned to either the museum program or a control group. The …

This study compares pregabalin alone versus pregabalin plus venlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. Researchers want to see if the combination provides better pain relief without more side effects. The trial will enroll 750 adults with moder…

This study tests a special hands-on therapy (osteopathic manual therapy) for jaw pain in people with fibromyalgia. Researchers want to see if it reduces pain, improves jaw function, and boosts quality of life. The study will involve 114 adults with both fibromyalgia and long-term…

This study compares pregabalin alone versus pregabalin plus dexmedetomidine for treating fibromyalgia, a condition causing widespread pain and fatigue. Researchers want to see if the combination provides better pain relief without more side effects. The study will enroll 400 adul…

This study tests two medications, pregabalin and a newer drug called crisugabalin, to see which works better for fibromyalgia pain. About 1,100 adults with moderate to severe fibromyalgia will take one of the drugs and report their pain levels. The goal is to find a more effectiv…

This study tests whether acupuncture can make opioid painkillers work better for people with fibromyalgia. About 45 adults who already take daily opioids will receive either real or fake (sham) acupuncture, then their pain response to an opioid will be measured. The goal is to se…

This study compares two different exercise programs plus dietary advice to see which better reduces symptoms in people who have both fibromyalgia and irritable bowel syndrome (IBS). Thirty adults aged 30 to 65 with moderate to severe IBS and confirmed fibromyalgia will participat…

This study tests whether adding a gentle, non-invasive brain stimulation technique called tDCS to a standard pain coping program can further reduce pain and improve daily life in people with fibromyalgia. About 68 adults with fibromyalgia will receive either real or fake tDCS alo…

This study tests whether taking oral magnesium can reduce pain and other symptoms in people with fibromyalgia who haven't gotten better with standard treatments. Researchers will enroll 86 adults aged 18-65 and measure changes using a special questionnaire. The goal is to see if …

This study tests an experimental drug called AXS-14 for managing fibromyalgia, a condition that causes widespread pain and fatigue. About 620 adults with fibromyalgia will take the drug or a placebo to see if it helps control symptoms longer. The main goal is to measure how long …

This early-phase study tests whether MDMA-assisted therapy can reduce pain and improve the bond between patients and therapists for people with fibromyalgia. Twenty adults with fibromyalgia will receive two therapy sessions with MDMA while their brain activity is scanned. The goa…

This study compares taking pregabalin alone versus pregabalin combined with desvenlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. Researchers want to see if the combination provides better pain relief without more side effects. The study will involve 3…

This study tests a small, FDA-cleared device placed on the ear that uses mild electrical pulses to stimulate nerves, aiming to reduce pain and improve daily function in veterans with fibromyalgia. Researchers will compare the real device to a sham (fake) version in 240 veterans t…

This study looks at whether a digital sleep therapy program (Sleepio) can help adults with fibromyalgia who also have trouble sleeping. About 142 participants will use the program at home for 10 weeks or receive standard sleep advice. Researchers will track changes in quality of …

This study tests whether a 6-week virtual reality exercise program can reduce the impact of fibromyalgia on daily life. 80 adults with fibromyalgia will be randomly assigned to either VR-enhanced exercise or standard exercise. The goal is to see if VR improves pain, fatigue, slee…

This study compares the pain-relieving effects of pregabalin alone versus pregabalin combined with toludesvenlafaxine in people with fibromyalgia. Fibromyalgia causes widespread pain, fatigue, and mood issues, and current treatments often provide only modest relief. The study wil…

This study compares a video-based exercise program (exergame) using Nintendo Switch Ring Fit Adventure to a standard home exercise program in women aged 30-70 with fibromyalgia. The goal is to see if the game-based approach improves pain, balance, mobility, and quality of life mo…

This study is testing a full-body suit that uses mild electrical pulses to help people with conditions like multiple sclerosis and fibromyalgia who experience muscle stiffness, spasms, or pain. About 15 adults will try the suit to see if it improves balance and reduces symptoms. …

This study explores whether core shamanism, a traditional healing practice, can reduce pain and other symptoms in people with fibromyalgia. Researchers will track attendance, pain levels, and changes in heart rate, breathing, and brain activity. The goal is to see if this approac…

This study tests a non-invasive magnetic brain stimulation technique called deep rTMS for people with long-term nerve pain or fibromyalgia. About 70 adults will receive either real or fake (sham) treatment over 3 months to see if it safely reduces pain. The goal is to find a new …

This study tests a new, noninvasive treatment for fibromyalgia that uses ultrasound to gently stimulate a part of the brain linked to pain. About 180 adults with fibromyalgia will receive either the real treatment or a sham (fake) version over four sessions in one month. Research…

This study tests whether a short behavioral treatment delivered over Zoom can help adults with fibromyalgia, lupus, chronic pelvic pain, or chronic low back pain learn ways to reduce pain and disability. About 125 participants will take part. The goal is to see if this approach i…

This study explores whether herbal medicines, vitamin IV therapy, and supplements can reduce symptoms of anxiety, arthritis, fibromyalgia, chronic pain, and high blood pressure. About 25 participants will receive natural treatments aimed at improving health and quality of life. T…

This study is testing whether an online course can help people with multiple sclerosis, long COVID, fibromyalgia, or cancer-related fatigue adopt healthier diets and self-care habits. Researchers will measure changes in quality of life, fatigue, and mental health. The goal is to …

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain, as well as healthy volunteers, over four months. The goal is to find patterns that predict whether pain becomes long-term, improves, or flares up. A smal…

This study aims to improve how doctors diagnose and treat chronic musculoskeletal pain (lasting over 12 weeks) from conditions like arthritis, fibromyalgia, and low back pain. Researchers will test a simple questionnaire and pain sensitivity assessments to see if they can identif…

This study looks at how different colors of light can change pain perception by measuring brain activity. Researchers will compare people with chronic muscle or fibromyalgia pain to healthy volunteers. Participants undergo brain scans while viewing colored lights and receiving mi…

This study looks at how brain networks synchronize in people with fibromyalgia, a condition causing widespread pain. Researchers will compare brain activity in 150 participants (patients and healthy volunteers) and test a gentle, non-invasive brain stimulation technique called HD…

This study looks at two substances in the blood, S100B and BDNF, to see if they are linked to pain sensitivity and poor sleep in people with fibromyalgia. Researchers will compare 60 women with fibromyalgia to healthy women. The goal is to better understand what causes fibromyalg…

This study looks at how long-term pain from knee problems or fibromyalgia changes the way the brain talks to muscles. Researchers will measure pain sensitivity and muscle activity in 135 adults aged 40 and older, including healthy volunteers. The goal is to better understand chro…

This study is working to create a new, objective way to measure pain in children with juvenile arthritis, lupus, or fibromyalgia. Researchers will follow 90 children for one year, collecting data during regular clinic visits. The goal is to replace the current trial-and-error app…

This study tests whether people with fibromyalgia can learn to control their own brain activity using real-time brain scans (fMRI) to reduce chronic pain. Participants will attend 8 weekly sessions with a pain psychologist and be randomly assigned to either cognitive behavioral t…

This study looks at whether internet-based exposure cognitive behavioral therapy can change how the brain processes pain in people with fibromyalgia. About 45 adults with fibromyalgia will undergo pain tests before and after treatment to measure pain thresholds, tolerance, and th…

This study looks at how fibromyalgia-related pain sensitivity (called central sensitization) is linked to problems with thinking, memory, and focus, often called 'brain fog.' Researchers will test 100 adults with fibromyalgia using questionnaires and cognitive tests to understand…

This study looks at how people with fibromyalgia or rheumatoid arthritis experience pain differently. Researchers will measure pain thresholds in 150 adults to better understand the underlying pain mechanisms. The goal is to improve knowledge, not to test a new treatment.

This study uses a special PET scan to measure brain inflammation in people with fibromyalgia, chronic fatigue syndrome, multiple sclerosis, and healthy volunteers. The goal is to see if those with pain and fatigue have higher levels of brain inflammation. Researchers will compare…

This study looks at how emotions and brain inflammation relate to pain in 60 veterans with fibromyalgia. Researchers will measure pain, mood, and inflammation markers, then use that information to design an exercise program that veterans can stick with. The goal is to better unde…

This study is collecting information from 200 people with cerebral palsy, multiple sclerosis, stroke, fibromyalgia, or similar nerve disorders to see how the EXOPULSE suit affects their balance and walking over time. Participants will be followed during routine care, and research…

This study explores whether a sham (fake) neurofeedback system in a virtual reality environment can change brain wave patterns related to attention. Researchers will compare positive and negative sham feedback to no feedback in 35 adults with rumination, chronic pain, or fibromya…