Could MDMA help ease fibromyalgia pain? early trial launches

NCT ID NCT06066853

Recruiting now Symptom relief Sponsor: Spaulding Rehabilitation Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 30, 2026 · Updated 3 times

Summary

This early-phase study tests whether MDMA-assisted therapy can reduce pain in 20 adults with fibromyalgia. Participants receive MDMA combined with psychotherapy and undergo brain scans to see how the drug affects pain and the bond between patient and therapist. The goal is to understand the brain mechanisms behind any pain relief, not yet to prove a treatment works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MDMA (combined with psychotherapy)
What this could lead to: If it works, this could point toward a new treatment option for fibromyalgia pain that also improves the patient-therapist relationship.
What could go wrong: This is a very early, small trial with only 20 people. It is designed mainly to study brain mechanisms, not to prove effectiveness, and MDMA has known risks like increased heart rate and psychological distress.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

fibromyalgia Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FIBROMYALGIA

Contacts and locations

Locations

Massachusetts General Hospital
RECRUITING

Charlestown, Massachusetts, 02114, United States

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