FIBROMYALGIA

This study tests whether a daily probiotic supplement, Bifidobacterium adolescentis PRL2019, can reduce pain in young people aged 9 to 25 with juvenile fibromyalgia, a condition marked by widespread musculoskeletal pain. Participants will take the probiotic or a placebo for 12 we…

This trial tests whether adding mandala coloring sessions to usual care can reduce pain, fatigue, and sleep troubles in adults with fibromyalgia. Sixty participants will be randomly assigned to either eight supervised coloring sessions over four weeks or to continue their routine…

This trial tests whether pain reprocessing therapy (PRT) — a brief psychological treatment that combines education, cognitive restructuring, and body-focused techniques — can reduce chronic pain. Adults with persistent pain lasting over three months are randomly assigned to full …

Fibromyalgia causes widespread pain, sleep problems, and fatigue. This trial tests whether a structured breathing technique called box breathing — inhaling, holding, exhaling, and pausing for 4 seconds each — can improve sleep quality, pain, and comfort. Sixty adults with fibromy…

This study investigates whether major ozone autohemotherapy — a procedure where a small amount of blood is mixed with ozone and returned to the body — can improve pain, fatigue, sleep, and muscle health in women with fibromyalgia. Sixty participants will receive either exercise a…

This study tests whether an artificial intelligence (AI) and computer vision system can help people with fibromyalgia perform effective exercise at home. Participants use a smartphone or tablet app that watches their movements and gives real-time feedback, with or without added r…

This study tests a self-guided digital psychology app, called Manage My Pain, along with weekly email reminders, for people with fibromyalgia or chronic pelvic pain who are on a waitlist for specialized pain care. The goal is to see if this approach is feasible and acceptable, an…

This study tests a hands-on technique called manual diaphragmatic release in 60 women with fibromyalgia who are not very active. The goal is to see if it improves exercise capacity, breathing muscle strength, symptoms, and quality of life. Participants will be randomly assigned t…

This study tests a new program called Empowered Relief for Caregivers (ER-CY), a single two-hour online class for caregivers of children and teens with chronic pain. Up to 80 caregivers will take the class and complete surveys and interviews over three months. The goal is to see …

This study will test whether sensory motor training for neck muscles, combined with nerve gliding exercises, can improve hand grip strength in 50 post-menopausal women with fibromyalgia-related neck pain. Participants will do laser-guided neck movements and nerve stretches for fo…

This study tests whether a safe electrical stimulation device placed on the ear (taVNS) can relieve chronic pain in people with fibromyalgia. Sixty participants will use the device twice daily for four weeks. Researchers will measure changes in pain, mood, and daily function to s…

This study tests whether a supplement called FibroThol (containing 2-Aticyto Complex and D-ribose) can help reduce pain and other symptoms in people with fibromyalgia. About 200 adults aged 18 to 65 who have had fibromyalgia for at least a year and are already on standard medicat…

This study compares two drugs, gabapentin and oxcarbazepine, for treating chronic nerve pain in children aged 8 to 18. Sixty participants will receive one drug or the other in a blinded fashion, with the option to switch if pain doesn't improve. The goal is to see which drug redu…

This study tests whether a device called Lymphatic Enhancement Technology (LET) can reduce pain and improve quality of life in women with fibromyalgia. Forty participants will receive either active or sham LET treatments once a week for four weeks. Researchers will measure change…

This study looks at whether adding special brain exercises to online Pilates classes can improve memory, attention, and pain in women with fibromyalgia. Thirty women will do Pilates twice a week for 8 weeks, with some also doing kinesthetic brain exercises. Researchers will measu…

This study tests whether adding tizanidine (a muscle relaxant) to pregabalin (a standard pain drug) works better than pregabalin alone for fibromyalgia pain. About 164 adults with daily pain will be followed for 12 weeks. The goal is to see if the combination reduces pain and imp…

This study tests a 12-week home program that combines AI-guided exercises with pain education for adults with fibromyalgia. Half of the 50 participants will use the digital program, while the other half receives usual care. The goal is to see if this approach reduces pain and imp…

This study tests whether a simple breathing exercise, called inspiratory muscle training, can improve the body's stress response and reduce symptoms like pain, fatigue, and sleep problems in women with fibromyalgia. Fifty-one women will be randomly assigned to real training, a sh…

This study looks at how resilience and pain sensitivity influence physical function in people with fibromyalgia compared to healthy volunteers. Researchers will measure walking distance using a 6-minute walk test and compare it to self-reported resilience scores. No treatment is …

This study looks at how whole-body heat therapy (hyperthermia) changes body temperature, pain sensitivity, and pain during movement in 60 people—half with chronic widespread pain (like fibromyalgia) and half healthy. Participants will receive six heat sessions over three weeks. T…

This study tests whether green light therapy can reduce pain in people with fibromyalgia by calming brain inflammation. Researchers will use brain scans and spinal fluid tests to see how the light affects pain pathways. The trial involves 70 adults with moderate to severe pain wh…

This study uses artificial intelligence to understand how sleep quality, fatigue, and emotional well-being affect the severity of fibromyalgia. Researchers will collect data from 150 adults with fibromyalgia through questionnaires. The goal is to build a model that predicts disea…

This study will compare women with fibromyalgia to healthy women to see how their symptoms, mental health, sleep, eating habits, and stomach issues differ. Researchers will use questionnaires and surveys to gather information from 80 women. The goal is to better understand the ma…

This study looks at how being sedentary versus active affects people with fibromyalgia. Researchers will compare 66 adults on body awareness, breathing strength, fear of movement, pain sensitivity, daily function, and sleep quality. The goal is to understand how inactivity may wo…

This study will check how often fibromyalgia occurs in women with polycystic ovary syndrome (PCOS) and how pain relates to mood and insulin resistance. About 140 women aged 18-40 with PCOS and a healthy control group will answer questionnaires and have pain thresholds measured. T…