Rewiring the brain to silence chronic pain — a bold psychological therapy is put to the test
NCT ID NCT07724808
First seen Jul 24, 2026 · Last updated Jul 24, 2026
Summary
This trial tests whether pain reprocessing therapy (PRT) — a brief psychological treatment that combines education, cognitive restructuring, and body-focused techniques — can reduce chronic pain. Adults with persistent pain lasting over three months are randomly assigned to full PRT, a version without the somatic component, or usual care. Researchers use brain scans, EEG, and wearable monitors to track changes and identify who might benefit most.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- pain reprocessing therapy (PRT), a psychological intervention combining psychoeducation, cognitive restructuring, and somatic elements
- What this could lead to
- If it works, this could point toward a drug-free, personalized treatment for chronic pain that targets the brain's role in pain.
- What could go wrong
- This is a relatively small, early-stage trial. The therapy may not work for everyone, and benefits could be modest or short-lived.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Ben-Gurion University of the Negev
Beersheba, Israel
Contact Phone: •••-•••-•••• Email: •••••@•••••
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