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Could cannabis replace opioids for chronic pain?

NCT ID NCT06206252

Disease control Sponsor: Thomas Jefferson University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 03, 2026 · Last updated Sep 04, 2026 · Updated 1 time

Summary

Researchers are testing whether medical cannabis can reduce pain and opioid use in people with chronic pain. Participants who already take prescription opioids will either opt to use medical cannabis or not for three months. Those in the cannabis group will try different THC and CBD combinations, and everyone will track their pain and daily opioid use. The goal is to see if cannabis can help lower opioid doses while keeping pain under control.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Medical cannabis (tincture or vaporization) with varying THC and CBD compositions
What this could lead to
If it works, medical cannabis could offer a way for people with chronic pain to cut down on opioid painkillers, potentially lowering the risk of dependence and side effects.
What could go wrong
The study is small and observational, so it may not prove cause and effect. Cannabis can cause side effects like drowsiness or dizziness, and results may not apply to everyone with chronic pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

110 people

The number who actually took part.

Started

Sep 2023

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

A total of 110 individuals with chronic pain who use prescribed opioids (90 medical cannabis users, 20 non-users) and live in Pennsylvania will be recruited for this study.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Current diagnosis of chronic, intractable pain * Use of prescription opioids for longer than 90 days * Have a smartphone or agree to use one provided * English fluency * Medical cannabis group only: Willing to get certified by a physician to use medical cannabis in PA OR already certified but have not been using medical cannabis products regularly (daily or weekly) for longer than 30 days * Medical cannabis group only: Willing to accept a temporary restriction on medical cannabis products * Control group: Agree to continue not using cannabis for the duration of the study (3 months) Exclusion Criteria: * Under 18 years old * Being under conservatorship * Self-reported pregnant or breastfeeding * Cannabis Use Disorder * Active treatment in methadone or buprenorphine program for Opioid Use Disorder * Diabetic neuropathy or chemotherapy-induced neuropathy alone * Medical cannabis group: Cannabis use (daily/weekly) for more than 30 days * Control group: Cannabis Use

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic pain Pain

Contacts and locations

Locations

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania, 19107, United States

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