Complex regional pain syndrome

This study tests a new way to help people with chronic non-cancer pain who have been on long-term opioids. Instead of usual care, a team of doctors, pharmacists, physiotherapists, and psychologists works with the patient to create a personalized plan. The goal is to reduce pain i…

This study tests whether counseling plus a muscle relaxant (tizanidine) can help adults who have used opioids for a long time reduce their pain medication after elective surgery. About 375 participants will be randomly assigned to one of three groups: the combo treatment, counsel…

This pilot study tests whether a 14-day course of prednisone, an anti-inflammatory steroid, can prevent complex regional pain syndrome (CRPS) after wrist fracture surgery. CRPS is a painful complication that can lead to long-term disability and increased opioid use. The study wil…

This study follows 2,000 people with chronic pain who are implanted with Abbott neurostimulators (spinal cord or dorsal root ganglion stimulators). Researchers will track side effects, device problems, and how well the devices control pain over time. It is an observational study,…

This study compares an online program called Veteran ACT for Chronic Pain (VACT-CP) to another online pain program, Online Pain School, for veterans with chronic pain. The goal is to see which program better helps veterans improve their daily functioning, manage pain, and enhance…

This phase 3 trial tests whether the drug neridronate, given as four IV infusions over 10 days, can reduce pain and other symptoms of complex regional pain syndrome type 1 (CRPS-1). About 270 adults with CRPS in one limb will receive either the drug or a placebo. The main goal is…

This study is testing a new type of spinal cord stimulator that automatically adjusts its signal based on how your nerves respond. It aims to improve pain relief and quality of life for 25 adults with long-term, hard-to-treat pain in the trunk or limbs. The device is already appr…

This study tests whether transcranial magnetic stimulation (TMS) can reduce pain and improve thinking, mood, and physical function in people with Complex Regional Pain Syndrome (CRPS). Forty adults with CRPS will receive either real TMS or a sham treatment for two days. Researche…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce pain in people with Complex Regional Pain Syndrome (CRPS). Thirty-two adults with active CRPS will receive either real or sham stimulation over several sessions. The goal is to see if this …

This study tests whether dance therapy can help teens aged 12-20 with chronic pain feel better and move more freely. 160 participants will either attend weekly dance sessions for 15 weeks or receive standard care. The goal is to see if dancing reduces pain intensity and fear of m…

This study tests whether sleeping with a weighted blanket (about 10% of your body weight) can help adults with chronic pain feel better. About 44 people will use the blanket every night for 5 weeks and report changes in pain, sleep, and daily activities. The goal is to see if thi…

This study is testing a new way to use an already-approved spinal cord stimulator to treat chronic, hard-to-manage back and leg pain. The device sends mild electrical pulses to the spine, and the new setting (called TVP-SCS) varies the timing of those pulses. Researchers will enr…

This study compares two online treatments for chronic pain: an 8-week cognitive behavioral therapy program (16 hours total) and a single 2-hour pain relief skills class. Researchers want to see which works better for reducing pain intensity and interference. The study will enroll…

This study is tracking 970 adults with chronic pain who receive an Inceptiv™ spinal cord stimulator, a device that sends mild electrical pulses to the spine to block pain signals. Researchers want to see if at least half of patients get significant pain relief and better quality …

This study looks at whether yoga-based occupational therapy can improve body awareness and daily function in adolescents aged 11-21 with chronic pain. Participants will attend 8-12 weekly yoga sessions and complete questionnaires before and after treatment. The goal is to see if …

This study tests a group-based parent training program called SPACE-Pain, originally developed for anxiety, to see if it is feasible and acceptable for parents of children aged 10-17 with chronic pain. The program teaches parents to reduce accommodation while staying warm and sup…

This study is testing whether a painless brain stimulation technique called tDCS can reduce chronic pain in 100 military members and veterans. Participants will receive tDCS while taking part in a behavioral health program, and researchers will track changes in pain levels and da…

This study tests a high-CBD, low-THC sublingual product against a placebo in 25 adults with chronic pain conditions like arthritis or injury-related pain. Over 9 weeks, researchers will track pain levels, medication use, quality of life, and thinking skills to see if CBD offers r…

This study tests whether a 6-week group pain education program can help people with chronic pain become more active, feel less pain, and have lower depression. Fifty adults with pain lasting over 3 months will attend weekly 2-hour sessions covering sleep, stress, exercise, pain s…

This study tests a faster form of brain stimulation (accelerated TMS) for people with long-term chronic pain that hasn't improved with medication. Researchers will use a smart algorithm to choose the best spot to stimulate each person's brain, based on their individual pain patte…

This study is testing whether a single injection of botulinum toxin (similar to Botox) around major nerves can safely reduce pain in people with Complex Regional Pain Syndrome (CRPS), a chronic condition causing severe pain and disability. Twenty adults with CRPS in one arm or le…

This study looks at whether combining mindfulness training (MBSR) with an open-label placebo—a pill that patients know has no active drug—is a practical way to help people with chronic pain. Researchers will randomly assign 45 adults to receive either mindfulness alone, the place…

This study tests a non-invasive brain stimulation technique called HD-tDCS for people with chronic pain that hasn't improved with other treatments. 144 participants will be randomly assigned to receive either real (anodal or cathodal) or sham (placebo) stimulation over five sessi…

This study tests whether task-based mirror therapy can reduce pain, swelling, and improve arm function in stroke survivors who develop shoulder-hand syndrome. Thirty-four participants aged 45-75 will be split into two groups: one doing mirror therapy plus standard exercises, the …

This study tests whether a team of five pain specialists—including doctors, psychologists, pharmacists, dietitians, and physical therapists—can help veterans with chronic pain feel better and get more out of life. About 150 veterans will either join the program right away or wait…

This study tests a smartphone app called QoLibri designed to help people with chronic pain manage their symptoms and improve their quality of life. About 410 adults with moderate or worse pain lasting over 3 months will be randomly assigned to use the app right away or after a wa…

This study looks at whether using a nerve stimulator in short bursts (30 seconds on, 90 seconds off) can provide the same or better pain relief as continuous stimulation. It involves 30 adults who have had a dorsal root ganglion stimulator for at least a year and report at least …

This study looks at whether teaching older adults about how pain works, combined with supervised exercise, can reduce chronic pain and improve daily life. One hundred people aged 65 and older with pain lasting over 3 months will be split into three groups: exercise only, exercise…

This study tests a single online class called Empowered Relief, delivered in Spanish to adults with chronic pain. The class teaches pain relief skills, and participants fill out surveys right after, at 2 weeks, and at 1 month. The goal is to see if the class is helpful and satisf…

This study is testing a smartphone app called Digital SPA, designed with input from teens, to help adolescents aged 12–17 manage chronic pain. The app uses Acceptance and Commitment Therapy techniques to reduce pain interference and emergency room visits. About 195 teens and thei…

This study tests whether adding a non-invasive brain stimulation technique called tDCS to a structured exercise program can reduce pain and disability in adults with chronic spinal pain that hasn't improved with usual care. Forty-two participants will be randomly assigned to rece…

This study tests whether a spinal cord stimulator can reduce long-term leg pain in people who still have pain after lumbar spine surgery. Fifty adults aged 18-70 who have not improved with other treatments will receive either active stimulation or sham (no stimulation) for 3 mont…

This study tests whether a combination of psilocybin (the active ingredient in magic mushrooms) and talk therapy can help adults with chronic pain safely reduce or stop their opioid painkillers. Ten participants will receive one or two psilocybin sessions over 8 weeks, with follo…

This study tests a personalized approach to magnetic brain stimulation for people with chronic pain. Instead of a one-size-fits-all treatment, researchers will use each person's brain signals to customize the stimulation. The goal is to improve pain relief for the 90 participants…

This study tests whether using a closed-loop spinal cord stimulator early in complex regional pain syndrome (CRPS) works better than waiting until the chronic phase. The device automatically adjusts its settings based on the body's signals. Researchers will enroll 32 adults with …

This study compares two short behavioral therapies—mindfulness (B-MORE) and cognitive-behavioral therapy (CBT)—for adults with chronic pain. Both treatments are just two hours long and offered in English or Spanish. The goal is to see if these brief programs are practical and acc…

This study tests whether wearing compression garments (gloves or sleeves) can reduce nerve pain in people with Complex Regional Pain Syndrome (CRPS) of the upper limbs. Sixty participants will either receive usual care plus the garment or usual care alone for three months. Pain l…

This study tests whether combining brain stimulation (rTMS), personalized physical therapy, and medication adjustments can reduce pain and improve daily function in people with Complex Regional Pain Syndrome (CRPS). Researchers will enroll 156 adults whose symptoms began within t…

This study tests a new program called PREP-Y, designed to help adolescents aged 12-17 with chronic musculoskeletal pain become more physically active and better manage their pain. The program includes four weekly virtual sessions teaching resilience skills like motivation and cop…

This study tests whether a personalized rehabilitation program helps people with persistent spinal pain syndrome type II (failed back surgery syndrome) return to work after receiving a spinal cord stimulator. 112 participants will be randomly assigned to either the personalized p…

This study tests whether a stellate ganglion block—a numbing injection near a nerve cluster in the neck—can reduce pain and improve arm function in stroke patients who develop complex regional pain syndrome. About 32 adults will receive the injection plus standard physical therap…

This study tests whether adding shiatsu—a gentle Japanese bodywork therapy—to standard medical care can improve quality of life for children aged 10 to 18 with chronic non-inflammatory pain. About 40 participants will receive one 30-minute shiatsu session per week for six weeks a…

This study follows 105 adults with chronic pain, nerve damage, or slow wound healing from cancer treatments. They receive ozone therapy as an add-on to their usual care. Researchers track changes in quality of life, anxiety, and depression to see if ozone therapy helps.

This study evaluates a questionnaire called the Emotional Allodynia Questionnaire (AEQ), which measures how people with fibromyalgia react emotionally to everyday social cues. Researchers want to see if the tool can reliably identify fibromyalgia and tell it apart from other type…

This study asks 200 adults with chronic pain about their preferences between pain relief and common side effects like drowsiness, nausea, or addiction risk. Participants rate how much each side effect bothers them compared to the benefit of pain relief. The goal is to help doctor…

This study tests whether a special band-aid (called the A-Band) and a smartwatch can measure pain in women with chronic pain using AI. About 115 women with chronic pain and healthy women will wear the devices for a week and report their pain levels. The goal is to see if the devi…

This study will look at the medical records of 15,000 people with chronic pain to see how well different treatments, like spinal cord stimulation, worked for them. The goal is to learn which approaches provide the best pain relief. No new treatments are being tested; instead, res…

This study uses brain scans (fMRI) and sensory tests to explore how different types of chronic pain affect the brains of children and teens aged 10-17. Researchers hope to find shared and unique brain patterns across conditions like migraines, fibromyalgia, and abdominal pain. Th…

This study looks at how mindfulness meditation and self-hypnosis work in the brains of adults aged 60 and older who have had chronic pain for at least 3 months. Participants will be randomly assigned to mindfulness, hypnosis, or story listening, and will undergo brain scans and E…

This study looks at how long-term opioid therapy changes brain and spinal cord activity in women with chronic pain. Researchers will compare brain scans of women with chronic pain and/or opioid use to healthy women. The goal is to find new ways to treat chronic pain without relyi…

This study compares two widely used drug classes—anti-convulsants and anti-depressants—for treating chronic pain in 450 real-world patients. Unlike typical trials that exclude many patients, this one includes people with other health issues to get results that apply to more peopl…

This study looks at 600 teens and young adults (ages 14-26) with conditions like juvenile arthritis, fibromyalgia, or past surgeries to understand why some develop long-lasting pain while others don't. Researchers will examine pain sensitivity, immune markers, and social factors …

This study explores how dopamine, a brain chemical linked to motivation, influences chronic pain. Ten adults with chronic pain will receive two dopamine-boosting drugs (methylphenidate and carbidopa-levodopa) or a placebo, then undergo brain scans to measure changes in key pain-r…

This study looks at whether a type of IV line called a midline catheter can be used safely and effectively for repeated lidocaine infusions in an outpatient clinic. About 500 adults with chronic pain will receive ten lidocaine infusions through a midline catheter. Researchers wil…

This pilot study looks at how lowering doses of pain medications like opioids and gabapentinoids changes the way the spinal cord responds to closed-loop spinal cord stimulation. Twenty adults with failed back surgery syndrome will be followed during a 21-day trial and up to 6 mon…

This study aims to create a large e-cohort of 5,000 chronic pain patients using a smartphone app called eDOL. The app lets patients report their pain, treatments, and daily life, while doctors can monitor them through a web platform. The goal is to better understand chronic pain …

This study uses virtual reality to explore how people with upper limb exclusion (non-use of an arm or hand) perceive the space around them. Researchers will compare 60 participants—those with the condition and healthy controls—as they judge whether virtual objects are reachable. …

This study is observing 120 people with chronic pain to learn how to design a more effective pain clinic. Researchers will track pain levels, medication use, and overall well-being. The goal is to understand what patients need, not to test a new treatment.

This study looks at how different pain medications change the way the spinal cord responds to a special type of spinal cord stimulator. The device automatically adjusts its stimulation based on nerve signals. Researchers will follow 50 people with chronic back pain who are either…

This study tests whether spinal cord stimulation can create artificial sensations, like tingling, and how changing stimulation settings affects those sensations. Ten adults with chronic pain who are already scheduled for spinal cord stimulation will participate. The goal is to be…

This study aims to find out if spinal cord stimulation (SCS) truly reduces pain or if the effect is just due to patients' expectations. Twenty-five adults with chronic pain who already have an SCS implant will take part in four test sessions. During each session, the stimulator w…

This study looks at whether taking prescription opioids for chronic pain changes the brain structure of adults aged 65 and older. Researchers will use MRI scans to measure brain changes over time. The goal is to understand the risks of long-term opioid use on brain health.

This study tests a new way to adjust spinal cord stimulation in 15 adults with chronic pain who already have spinal cord implants. Researchers will use electrical recordings called ECAPs to find the best stimulation settings. The goal is to see if this approach is feasible and ac…

This study uses a special thermal camera to take pictures of the feet of people with complex regional pain syndrome (CRPS) before and after they receive spinal cord stimulation. The goal is to see if the stimulation changes blood flow and temperature in the painful limb. Research…

This study looks at whether the bacteria in your gut are linked to the severity and recovery of Complex Regional Pain Syndrome (CRPS), a chronic pain condition. Researchers will compare gut microbiome samples from people with CRPS and their household members. They also aim to pre…

This study checks if a computer algorithm can correctly identify the cause of chronic pain, just like a pain specialist would. About 200 adults with pain lasting at least one month will have their symptoms and history analyzed by both the algorithm and a doctor. The goal is to se…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to find patterns that predict whether acute pain becomes chronic, or if chronic pain flares up. A smaller group will also ha…

This study looks at how spinal cord stimulation (SCS) changes certain molecules in the blood and spinal fluid of people with long-term nerve pain. Researchers will measure inflammatory markers and other signaling molecules before and after SCS in 30 adults. The goal is to underst…