Could a common steroid stop wrist fracture pain from becoming chronic?
NCT ID NCT06453447
First seen May 07, 2026 · Last updated Jun 23, 2026 · Updated 13 times
Summary
This pilot study tests whether a 14-day course of prednisone, an anti-inflammatory steroid, can prevent complex regional pain syndrome (CRPS) after wrist fracture surgery. CRPS is a painful complication that can lead to long-term disability and increased opioid use. The study will enroll 40 adults at risk of CRPS, randomly giving them either prednisone or a placebo for two weeks, and track outcomes like pain resolution and opioid consumption.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Vancouver General Hospital
RECRUITINGVancouver, British Columbia, V5Z 1M9, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Prednisone
What this could lead to
If it works, this could point toward a simple, short-term treatment to prevent chronic pain and disability after wrist fractures.
What could go wrong
This is a very small pilot study (40 people) focused on feasibility, not proof of effectiveness. Prednisone has side effects like weight gain and mood changes.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.