Radius fracture

This trial looks at two approaches for treating displaced wrist fractures in children aged 4 to 10. One group gets the standard sedated reduction (where the bone is realigned under sedation) followed by a cast. The other group gets only a cast without any realignment. The study m…

This study looks at whether giving less intravenous (IV) fluid to critically ill children with traumatic injuries leads to fewer complications. Currently, there is no standard for how much fluid these children should receive. The trial will enroll 250 children aged 6 months to 15…

This study compares two common surgeries for wrist fractures that involve the joint surface: a volar locking plate (a metal plate placed inside the wrist) and an external fixator (a frame outside the arm with pins into the bone). Researchers will measure how long the surgery take…

This pilot study tests whether a 14-day course of prednisone, an anti-inflammatory steroid, can prevent complex regional pain syndrome (CRPS) after wrist fracture surgery. CRPS is a painful complication that can lead to long-term disability and increased opioid use. The study wil…

This study compares two common surgical methods—cannulated screws and K-wires—for fixing broken wrists in adults aged 18-60. The goal is to see which approach leads to better bone healing and hand strength. About 34 participants will be assigned to one of the two treatments and f…

This study follows 300 people who receive the IlluminOss device to treat broken bones from injury or disease. Researchers will track how well the device works, how safely it performs, and how patients recover over time. The goal is to gather real-world data on bone healing and re…

This study compares two treatments for a specific type of wrist fracture in children under 11. One method uses a cast with finger-trap traction (no manual bone setting), while the other involves surgery with pins. The goal is to see which approach leads to better wrist movement, …

This study compares two treatments to help blood clot in severely injured trauma patients who are bleeding heavily. One is a standard frozen blood product (cryoprecipitate) that takes time to thaw, and the other is a dry powder (fibrinogen concentrate) that can be given at the be…

This study tests whether adding a collagen scaffold called Miro3D to standard wound care helps acute and chronic wounds heal better than standard care alone. About 70 adults with soft tissue wounds or pressure ulcers will be randomly assigned to one of two groups. The main goal i…

This study tests a special dissolvable hydrogel placed between the metal plate and tendons during wrist fracture repair. The goal is to see if it helps tendons move more smoothly and reduces the chance of tendon rupture. Fifty adults having wrist fracture surgery will be randomly…

This study looks at whether ultrasound can reliably detect broken bones in the elbow of children aged 5 to 15 after an accident. About 543 kids will get both an ultrasound and standard X-rays, and researchers will compare the results. If ultrasound proves accurate, it could offer…

This study tests whether using ultrasound instead of X-rays can diagnose elbow fractures in children more efficiently. About 225 kids with elbow pain will be randomly assigned to get either an ultrasound or an X-ray. Researchers will compare costs, radiation exposure, time spent …

This study tests whether a short form of exposure therapy, given soon after a traumatic injury, can prevent posttraumatic stress disorder (PTSD). Researchers will enroll 300 injured adults admitted to Level I trauma centers. Half will receive the brief therapy plus standard care,…

This study tests whether a therapist-guided exercise program helps people aged 50 and older recover better from a wrist fracture compared to usual care advice. Participants will either receive supervised exercises or standard self-management advice. The main goal is to see if the…

This study tests whether 2-3 ten-minute visits from a trained therapy dog can reduce pain, anxiety, depression, and anger in adults hospitalized after a traumatic injury. Researchers will compare patients who get dog visits to those who only get a visit from a dog handler. The go…

This study tests whether a soft robotic glove called Carbonhand can help people with hand weakness from injury or nerve conditions perform daily activities at home. Five participants will use the glove for six weeks while researchers measure arm activity, grip strength, and well-…

This study tests whether a short-arm fiberglass cast works as well as a long-arm cast for stabilizing certain forearm fractures in children aged 4 to 16. The goal is to see if the shorter cast provides enough support while being more comfortable. About 120 children with Salter Ha…

This study tests whether putting tranexamic acid (a medicine that helps blood clot) into the surgical wound before closing it can reduce pain and the need for painkillers after wrist fracture surgery. About 90 adults having surgery for a broken wrist will be randomly assigned to …

This study tests whether adding a lightweight SAM splint to usual pain relief helps adults with suspected wrist fractures feel less pain while waiting for X-rays in the emergency department. About 120 participants with moderate to severe pain will be randomly assigned to get a sp…

This study compares a nonopioid pain control plan to standard opioid pain medicine in 75 adults after surgery for a broken collarbone. The goal is to see if the nonopioid plan can control pain just as well while reducing opioid side effects and addiction risk. Participants are ra…

This study tests whether giving fluoxetine (Prozac) immediately after a serious injury can prevent depression, PTSD, and reduce pain and opioid use. About 200 adults with fractures or other bodily trauma will receive either fluoxetine or a placebo during their hospital stay. The …

This study tests a counseling program for caregivers of children hospitalized for a traumatic injury like burns or a car accident. The goal is to reduce PTSD and depression in both the caregiver and child. 24 caregiver-child pairs will be randomly assigned to either the counselin…

This study tests whether a single dose of ketamine given during surgery can help adults with serious orthopedic trauma recover better. Researchers want to see if it reduces pain, lowers the need for opioids, and improves symptoms of depression and PTSD. Ninety participants will b…

This study tests whether ketamine or fentanyl is better for pain relief in trauma patients with signs of shock. About 994 adults will receive one of the two drugs in the ambulance. Researchers will track survival at 24 hours and side effects like low oxygen or blood pressure.

This study tests whether using ultrasound to guide a numbing injection (hematoma block) works better than the traditional method of injecting without imaging for people with a broken wrist. About 115 adults in the emergency department will take part. The goal is to see which appr…

This study tests whether a special LED light bracelet, used at home for 12 minutes a day, can improve recovery after wrist fracture surgery. Forty-two adults will either get the active light device or an inactive one, along with standard exercises. Researchers will check wrist fu…

This study looks at whether doing daily activities early after a wrist fracture (treated with a cast) helps people recover better. 64 adults will be split into two groups: one gets instructions on how to safely use their injured hand, the other gets only cast care advice. Researc…

This study looks at whether older adults (65+) with a displaced wrist fracture can be treated with just a cast, without first straightening the bone (closed reduction). The trial will compare pain and disability at 12 months between those who get a cast only and those who get the…

This study tests whether a continuous intravenous infusion of magnesium sulfate can reduce pain and the need for narcotic painkillers in critically ill trauma patients admitted to the intensive care unit. Researchers will compare magnesium to a placebo (normal saline) in 156 adul…

This study tests a new way to fix certain wrist fractures using a local anesthetic called WALANT (which keeps you awake but pain-free) and a tiny camera (arthroscope) to guide the repair. The goal is to see if this combination is practical and improves precision, reduces risks, a…

This study tests if a longer-lasting painkiller (liposomal bupivacaine) works better than the standard one for wrist fracture surgery. About 100 adults will receive a nerve block before surgery, and their pain and recovery will be tracked for 48 hours. The goal is to find a way t…

This study tests two lighter pain control methods for children aged 3 to 17 who need a wrist fracture reduction. One method uses a numbing injection (hematoma block) with a low dose of ketamine, and the other uses the same block with fentanyl nasal spray. These are compared to th…

This Phase 2 trial tests whether 4-aminopyridine, a drug already used for other conditions, can speed up healing of skin wounds. Researchers will give the drug or a placebo to 150 healthy adults and measure how quickly small biopsy wounds close. The goal is to see if this safe, e…

This study looks at whether giving older trauma patients extra protein drinks (up to 3 times a day in the hospital and for 4 weeks after discharge) helps them regain muscle and function better than standard nutrition. Sixty adults aged 45 and older who can eat by mouth will be ra…

This study looks at records of 500 patients admitted to intensive care units in Colombia to find out what factors are linked to death after severe trauma. Researchers will compare trauma patients with other ICU patients using a discharge database. The goal is to better understand…

This study follows 300 people with a broken wrist (distal radius fracture) to understand their pain, hand function, and use of painkillers or splints during the first three months. Participants will fill out daily and weekly questionnaires. The goal is to learn what recovery real…

This study looks back at medical records of 4 severely injured trauma patients who needed large blood transfusions. It compares two drugs that help blood clot—prothrombin complex concentrate and recombinant activated factor VIIa—to see which causes fewer dangerous blood clots and…

This study aims to see if updated criteria for activating trauma teams can reduce mistakes—either calling a team when not needed (over-triage) or missing a serious case (under-triage). Researchers will compare data from 5,000 trauma patients before and after the new rules were pu…

This study follows 350 adults with major injuries admitted to intensive care. Doctors will use a non-invasive bedside ultrasound to check blood flow in the kidneys and liver at several time points. The goal is to see if certain ultrasound patterns are linked to acute kidney injur…

This study looks at whether fear of movement (kinesiophobia) can predict how well people recover after a wrist fracture treated without surgery. Researchers will measure fear levels, wrist motion, strength, and daily function in 34 adults. The goal is to understand if psychologic…

This study will enroll 188 trauma patients in Iraq to see how well three scoring systems (EMTRAS, REMS, and GAP) predict who will die, need a breathing tube, or stay longer in the hospital. Researchers will calculate each patient's score upon arrival and track their outcomes. The…

This study compares two scoring systems (TTSS and TRISS) to see which better predicts outcomes like death or ICU admission in people with chest injuries. Researchers will assess 150 patients in the emergency room and track their hospital course. The goal is to find the most accur…

This study looks at whether storing blood for a long time before transfusion affects death rates and complications in severely injured trauma patients. Researchers will review records of 300 patients aged 18-75 who received large transfusions. The goal is to understand if blood s…

This study looks at how severe traumatic injury changes the bone marrow and gut, leading to long-term anemia and microbiome disruption. Researchers will collect bone marrow, blood, and stool samples from 275 adults with serious blunt trauma. The goal is to understand these intera…

This study compares Advanced Trauma Life Support (ATLS) training for doctors against usual care to see if it improves survival in adult trauma patients. Over 4,000 patients from hospitals in India will take part. The goal is to find out if this widely used training actually saves…

This study looks at how severe injuries change the way bone marrow stem cells work, especially in older adults. Researchers will collect bone marrow and blood samples from 400 trauma patients to understand why some develop long-term anemia and muscle loss. The goal is to learn mo…

This study tests whether text messaging can help collect feedback from orthopedic patients about their recovery. Researchers will enroll up to 3,000 people with specific bone or spine injuries. The goal is to use this information to schedule clinic visits more efficiently, so pat…