Complex regional pain syndrome

This study tests a mobile app called DockTales, designed for adults with chronic pain. The app lets users track pain and sleep through short diaries, body maps, and journaling, with an optional AI feature for reflection. Researchers want to see if the app is easy to use and engag…

This study tests a new device called the EpiFaith™ Syringe, which gives a clear visual signal when a doctor reaches the right spot for an epidural pain injection. Currently, doctors rely on feel alone, which can lead to multiple needle sticks or mistakes. The study will compare t…

This study will follow 80 people with chronic pain (like back, hip, or nerve pain) who are getting a procedure called cryoneurolysis, which uses cold to temporarily block pain signals. Researchers want to see if it leads to meaningful pain relief and better daily function over 12…

This early-phase study at Yale will test whether a single 25mg dose of psilocybin is safe and well-tolerated in 10 veterans who smoke daily and have chronic pain. Researchers will monitor side effects and explore whether the drug can improve pain and boost motivation to quit smok…

This study tests a new program called Empowered Relief for Caregivers (ER-CY), a single two-hour online class for caregivers of children and teens with chronic pain. Up to 80 caregivers will take the class and complete surveys and interviews over three months. The goal is to see …

This study tests whether combining virtual reality games with physical therapy can reduce chronic pain in children aged 7 to 21. Twenty participants with pain in the head, neck, or upper limbs will attend six weekly sessions. They will play VR games designed to encourage movement…

This study compares two drugs, gabapentin and oxcarbazepine, for treating chronic nerve pain in children aged 8 to 18. Sixty participants will receive one drug or the other in a blinded fashion, with the option to switch if pain doesn't improve. The goal is to see which drug redu…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people with severe Complex Regional Pain Syndrome (CRPS). Researchers will measure pain levels, wrist movement, and daily function in 60 adults with CRPS. The goal is to s…

This study tests whether a 6-week virtual reality (VR) program can help adults with chronic pain learn about pain science and manage their symptoms. Fifty participants will use VR headsets for one hour each week to watch educational content and do guided exercises. The goal is to…

This phase 2 trial will test whether extended-release ketamine tablets can reduce pain in 65 adults with complex regional pain syndrome (CRPS), a chronic condition causing severe, often burning pain. Participants will take either 80 mg or 160 mg of ketamine daily for several week…

This study will compare cannabis, opioids, and two non-drug therapies (MIRE and TENS) in 1,000 people with chronic pain or circulatory disorders. The goal is to find safer, less addictive pain relief options. Researchers will measure changes in pain and nerve function using objec…

This European study will test a new type of spinal cord stimulation device in 200 people with persistent back and leg pain after failed back surgery. The device uses a special stimulation pattern to try to reduce pain. Researchers will track pain levels and device settings to see…

This study will test whether using a mind-body mobile app combined with a guided, gentle movement program can help people with chronic pain. One hundred adults aged 19 to 75 with persistent pain for at least 6 months will use the app daily and follow audio-guided movement session…

This study translates and tests a 9-question scale called BITEC, which measures what people with chronic pain expect from their treatment. Researchers will enroll 250 adults in Turkey who have had pain for at least three months. Participants fill out surveys about their pain, exp…

This study follows 800 people who are already scheduled to receive ketamine infusions for chronic pain as part of their regular care. Researchers will use surveys to track pain levels, opioid use, and overall well-being for up to 16 weeks. A comparison group includes patients who…

This observational study looks at how people with chronic pain experience pleasant touch and how often they encounter it in daily life. Researchers want to see if these experiences are linked to pain sensitivity and body awareness. About 100 adults referred to a pain clinic in Sw…

This study looks at whether using a stomach ultrasound before sedation can help anesthesiologists make safer decisions for chronic pain patients. These patients often take opioids or have other conditions that slow stomach emptying, raising the risk of food or liquid entering the…

This study tests whether a 10-15 minute educational session about the neuroscience of pain can improve memory and change how people with chronic pain sense their body. Fifty adults with pain lasting more than a year will take memory tests and draw their pain on a body chart befor…

This study looks at whether a single session of intense aerobic exercise can temporarily reduce pain sensitivity in 66 young people with and without chronic pain. Participants will walk or run on a treadmill, and researchers will measure how their pain perception changes. The goa…