Complex regional pain syndrome
MONDO:0019369A chronic pain syndrome characterized by a disproportionate spontaneous or stimulus-induced pain, accompanied by a variably mixed myriad of autonomic and motor disorders including symptoms such as swelling, allodynia, skin blood supply and trophic disturbances. CRPS most often affects one of the arms, legs, hands, or feet and usually occurs after an injury or trauma to that limb.
Also known as: CRPS, algoneurodystrophy, reflex sympathetic dystrophy
173 clinical trials for this condition and its sub-types.
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Broader categories
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Pain drug lyrica put to the test for rare limb condition – but trial stalls
Symptom relief TerminatedThis study tested whether adding pregabalin (Lyrica) to standard treatment could reduce pain and improve function in people with complex regional pain syndrome (CRPS) of the upper limb. Only 14 adults were enrolled before the trial was stopped early. The goal was to see if the dr…
Phase: NA • Sponsor: McMaster University • Aim: Symptom relief
Last updated Jun 27, 2026 13:08 UTC
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New burst stimulation for chronic pain studied – but trial stopped early
Symptom relief TerminatedThis study looked at a new type of spinal cord stimulation called burst stimulation (Burst-SCS) to see how it reduces chronic pain. It included 12 people with long-term pain, mostly from failed back surgery. The trial was terminated early, so the findings are limited and not conc…
Phase: NA • Sponsor: University of Michigan • Aim: Symptom relief
Last updated Jun 27, 2026 07:57 UTC
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Can changing how you think about pain reduce opioid cravings?
Knowledge-focused TerminatedThis study looked at whether people with chronic pain who tend to catastrophize (imagine the worst) about their pain experience stronger cravings for prescription opioids. Researchers measured cravings, stress hormones, and mood in 93 adults who had been taking opioids for at lea…
Phase: NA • Sponsor: Stanford University • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:04 UTC
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Tiny study on nerve stimulation for pain halted early
Knowledge-focused TerminatedThis study looked at a type of spinal cord stimulation (SCS) that doesn't cause tingling, called paresthesia-free SCS, in 10 adults with chronic pain. Researchers wanted to see how well it works and how it affects pain perception. The study was terminated early, so the findings a…
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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App-Based study aims to improve chronic pain tracking
Knowledge-focused TerminatedThis study looked at using a mobile app to collect feedback from 91 adults with chronic pain who were already receiving spinal cord stimulation (SCS) therapy. The goal was to see how well the app worked for gathering information on their pain and overall improvement. The study di…
Sponsor: MedtronicNeuro • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC