Complex regional pain syndrome

This study tests a new way of managing chronic pain by improving teamwork between pain clinics, GPs, and other services. About 386 adults referred to pain clinics in Norway will either get this new pathway or standard care. The goal is to see if better coordination and a clear 6-…

This study tests a type of spinal cord stimulation that uses low-level electrical pulses (below the sensation threshold) against the best available medical treatments for people with ongoing back and leg pain after back surgery. About 114 participants will be randomly assigned to…

This study uses a device that combines magnetic stimulation and brain wave recording (TMS-EEG) to find biological markers for chronic pain. Researchers will measure brain responses in 100 adults with chronic pain and see if these signals can help diagnose pain types and predict h…

This study tests a 9-week virtual group program that teaches mindfulness, yoga, nutrition, and self-massage to help people with chronic pain. It is being offered at Federally-Qualified Health Centers, which serve low-income patients. The goal is to see if the program can be succe…

This study tests whether a very low dose of naltrexone, a drug usually used for addiction, can reduce pain and other symptoms in people with Complex Regional Pain Syndrome (CRPS). Forty adults with CRPS will receive either the drug or a placebo for six months. The main goal is to…

This study tests a toolkit designed to help employees with chronic pain feel more confident managing their condition at work and stay productive. Over 600 workers from around 30 UK organizations will either use the toolkit or receive usual care. Researchers will measure work abil…

This study tests a spinal cord stimulator that delivers fast-acting pain relief without the usual tingling sensation. About 177 adults with long-term back and limb pain will use the device. The main goal is to see if at least half of them get 50% or more pain reduction after 3 mo…

This study tests whether adding a non-invasive brain stimulation technique called rTMS to a three-week intensive pain rehabilitation program can help youth aged 10-18 with severe chronic pain. The goal is to see if the stimulation can reduce pain and improve daily function, mood,…

This study explores whether low-intensity focused ultrasound (LIFU) can temporarily change brain activity to reduce chronic pain. Eighty adults with moderate-to-severe pain lasting at least 3 months will receive brain scans, pain tests, and questionnaires over 10 weeks. The goal …

This study looks at whether adding a mobile app that guides teens through physical exercise and mindfulness training can make standard pain rehabilitation more effective. About 60 teens aged 13-19 with long-term pain will either get the app plus a shorter hospital program, or the…

This study tests whether repeated magnetic pulses (rTMS) aimed at the brain's motor area can safely reduce chronic nerve pain that hasn't responded to other treatments. About 32 adults with conditions like post-stroke pain, trigeminal neuralgia, or spinal cord injury will receive…

This study planned to test whether a small vibrating bee with ice-pack wings, called Buzzy, could reduce pain during IV placement in adults with chronic pain who receive lidocaine infusions. Participants would have rated their pain and satisfaction after IV insertion. However, th…

This study tests whether daily listening to jazz music combined with mindfulness can reduce chronic pain and anxiety. About 90 adults with chronic pain and moderate-to-severe anxiety will listen to jazz recordings daily for 4 weeks. Researchers will measure changes in pain intens…

This study looked at whether taking a probiotic supplement for 8 weeks could reduce inflammation and pain in teenagers (ages 13-17) who have chronic pain and a body mass index at or above the 85th percentile. Researchers measured changes in a blood marker of inflammation (C-react…

This study looks at adults with chronic pain who receive ketamine infusions at Stanford's Pain Management Center. Researchers want to understand which patients improve and what factors predict a good response. The goal is to better tailor this treatment to individuals.

This study tests whether daily exposure to green LED light can reduce chronic pain. 55 adults with conditions like fibromyalgia or nerve pain will use a green or white light device at home for 2 hours each day over 3 months. Researchers will measure changes in pain levels, medica…

This study aims to develop a screening test for a pain control mechanism called DNIC, which is often faulty in people with chronic pain. Researchers will use cameras to capture facial expressions during pain tests and apply artificial intelligence to see if they can automatically…

This study looks back at medical records of 200 adults with Complex Regional Pain Syndrome (CRPS) to see which pain treatments doctors actually use first and how well they work. Researchers want to find patterns that could help choose the best treatment for each person. No new tr…

This study planned to use Apple Watches to track physical activity, diet, and environment in children with complex regional pain syndrome (CRPS) to identify what triggers sudden severe pain. However, the study was withdrawn before enrolling any participants, so no data was collec…

This study aims to see if a short, 4-question Turkish version of the Pain Anxiety Symptom Scale is a reliable and valid tool for measuring pain-related anxiety. Researchers will enroll 350 adults aged 18-65 who have had chronic pain for at least 3 months. Participants will fill o…

This study looks at whether matching adults with chronic pain to specific psychological treatments—like cognitive behavioral therapy, mindfulness, or hypnosis—based on their personal traits (such as brain activity or thinking patterns) leads to better pain relief. Researchers wil…

This study is enrolling 120 adults with Complex Regional Pain Syndrome (CRPS) to see if certain blood clotting factors are linked to how well they respond to neridronic acid treatment. Researchers will measure pain levels before and after treatment. The goal is to find markers th…

This study follows 100 people with combat-related limb injuries to see if the mechanics of the injury—like force and direction—can predict who will develop chronic pain. Researchers will track pain levels at 3 and 6 months. The goal is to find early warning signs so doctors can s…

This study aims to validate a self-report questionnaire that people with Complex Regional Pain Syndrome (CRPS) can fill out at home. Researchers will compare the self-report results with in-person clinical exams to see if the questionnaire accurately measures symptom severity and…

This study reviews the medical records of 20 adults who had a limb amputated to relieve severe, long-lasting pain from complex regional pain syndrome (CRPS). Researchers want to measure how many days pass between the amputation and when patients first use a functional prosthetic …

This study uses a driving simulator to test whether people with chronic pain can drive safely while taking oral opioids. 450 participants with a valid driver's license will be tested on measures like weaving and reaction time. The goal is to provide better guidance to patients an…

This study was designed to explore what kinds of feelings (like touch or tingling) could be created by electrically stimulating the spinal cord in people with amputations who experience phantom limb pain. Researchers planned to work with patients who already had a spinal cord sti…