Ketamine pills could ease debilitating CRPS pain – new trial underway
NCT ID NCT06419985
First seen Jun 27, 2026 · Last updated Jul 28, 2026 · Updated 2 times
Summary
This phase 2 trial will test whether extended-release ketamine tablets can reduce pain in 65 adults with complex regional pain syndrome (CRPS), a chronic condition causing severe, often burning pain. Participants will take either 80 mg or 160 mg of ketamine daily for several weeks. The study is open-label, meaning everyone knows they are getting the drug, and it focuses on pain scores, quality of life, and safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Ketamine extended-release tablets
- What this could lead to
- If successful, this could provide a new oral treatment option to ease chronic pain for people with complex regional pain syndrome.
- What could go wrong
- This is an early-phase, open-label trial with no placebo group, so results may be influenced by expectation. The small size (65 people) also limits how broadly findings can be applied.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Pain Center, Keck Medical Center of University of Southern California
Los Angeles, California, 90033, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a smart brain implant outsmart chronic pain?
- Magnetic pulses to the brain aim to quiet CRPS pain
- Pain drug lyrica put to the test for rare limb condition – but trial stalls
- Teens with chronic pain try dance as medicine
- Brain scans aim to unlock secrets of chronic pain in kids
- Apple watch study to track CRPS pain triggers in kids cancelled