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Could a Nerve-Zapping ear device ease chronic pain?

NCT ID NCT07711392

Not yet recruiting Symptom relief Sponsor: Liv Hospital Vadistanbul Source: ClinicalTrials.gov ↗

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This study tests whether adding a gentle electrical stimulation to the ear — targeting the vagus nerve — can improve pain and function in adults with complex regional pain syndrome type I (CRPS-I) affecting the hand or arm. All participants receive standard rehabilitation, but half also get active nerve stimulation while the other half gets a sham device. Researchers measure pain, swelling, hand function, and quality of life over 12 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
transcutaneous auricular vagus nerve stimulation (taVNS) added to standard rehabilitation
What this could lead to
If effective, this approach could offer a non-invasive, drug-free way to ease pain and improve daily function for people with CRPS.
What could go wrong
This is a small, early-stage trial with only 20 participants, so results may not apply widely. The treatment may not provide significant benefit over standard rehab alone.

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Conditions

The condition(s) this trial relates to.

complex regional pain syndrome complex regional pain syndrome type 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COMPLEX REGIONAL PAIN SYNDROME TYPE I

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

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