Could Botox-Like shots ease debilitating CRPS pain?
NCT ID NCT07473635
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing whether a single injection of botulinum toxin (similar to Botox) around major nerves can safely reduce pain in people with Complex Regional Pain Syndrome (CRPS), a chronic condition causing severe pain and disability. Twenty adults with CRPS in one arm or leg will receive the injection and be followed for 12 weeks. The main goal is to see if the procedure is practical and safe, not yet to prove it works.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Incobotulinumtoxin-A (a type of botulinum toxin, like Botox)
- What this could lead to
- If this approach is safe and feasible, it could lead to a larger trial testing whether botulinum toxin injections can reduce pain and flare-ups in CRPS.
- What could go wrong
- This is a very small, early feasibility study with only 20 people. It is not designed to prove the treatment works, and there is a risk of side effects or worsening pain from the injection itself.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
CRPS- and Nerve Pain Clinic, Rigshospitalet Glostrup
RECRUITINGGlostrup, Region Sjælland, 2600, Denmark
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Nerve block combo may ease chronic pain condition
- Wearable sensors reveal hidden body changes during nerve stimulation for CRPS pain
- Can special goggles reduce CRPS pain? new study tests prism therapy
- Could turning nerve stimulation on and off beat continuous therapy for chronic pain?
- Heat-Sensing camera could gauge CRPS pain severity
- New hope for CRPS sufferers: brain zaps and therapy combo put to the test