New hope for CRPS sufferers: brain zaps and therapy combo put to the test
NCT ID NCT07208825
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether combining brain stimulation (rTMS), personalized physical therapy, and medication adjustments can reduce pain and improve daily function in people with Complex Regional Pain Syndrome (CRPS). Researchers will enroll 156 adults whose symptoms began within the last 5 years. All participants will receive rTMS and basic rehabilitation, but the timing and addition of specialized neurological therapy will vary between groups. The goal is to find a better way to manage this often-debilitating condition.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- repetitive transcranial magnetic stimulation (rTMS), physical therapy, functional neurology, and medication optimization
- What this could lead to
- If successful, this could point toward a more effective, non-drug rehabilitation plan that helps CRPS patients better manage pain and return to work.
- What could go wrong
- This is an early-phase study with no placebo group, so results may not prove which part of the treatment works. CRPS is notoriously hard to treat, and full recovery is rare.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Oulu University Hospital, Pain Clinic
RECRUITINGOulu, North Ostrobothnia, 90100, Finland
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Other studies related to the condition(s) this trial covers.