Could a bone drug ease CRPS pain? large trial underway
NCT ID NCT07210515
First seen Jun 26, 2026 · Last updated Jul 01, 2026 · Updated 2 times
Summary
This phase 3 trial tests whether the drug neridronate, given as four IV infusions over 10 days, can reduce pain and other symptoms of complex regional pain syndrome type 1 (CRPS-1). About 270 adults with CRPS in one limb will receive either the drug or a placebo. The main goal is to see if pain levels drop more with neridronate after 12 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Neridronate (a bisphosphonate drug given intravenously)
What this could lead to
If it works, this could provide a new treatment option to reduce pain and severity of CRPS type 1.
What could go wrong
This is a phase 3 trial, but previous results may not guarantee success. The drug may not outperform placebo, and side effects from IV infusions are possible.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Ambros Clinical Trial Site
RECRUITINGPhoenix, Arizona, 85032, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ambros Clinical Trial Site
RECRUITINGTucson, Arizona, 85710, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ambros Clinical Trial Site
RECRUITINGNapa, California, 94558, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ambros Clinical Trial Site
RECRUITINGPasadena, California, 91105, United States
Contact Email: •••••@•••••
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Ambros Clinical Trial Site
RECRUITINGTustin, California, 92780, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ambros Clinical Trial Site
RECRUITINGWashington D.C., District of Columbia, 20006, United States
Contact Email: •••••@•••••
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Ambros Clinical Trial Site
RECRUITINGBrandon, Florida, 33511, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ambros Clinical Trial Site
RECRUITINGPembroke Pines, Florida, 33025, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ambros Clinical Trial Site
RECRUITINGNewnan, Georgia, 30265, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ambros Clinical Trial Site
RECRUITINGChicago, Illinois, 60640, United States
Contact Email: •••••@•••••
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Ambros Clinical Trial Site
RECRUITINGOrland Park, Illinois, 60462, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ambros Clinical Trial Site
RECRUITINGCharlotte, North Carolina, 28211, United States
Contact Email: •••••@•••••
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Ambros Clinical Trial Site
RECRUITINGWilmington, North Carolina, 28412, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ambros Clinical Trial Site
RECRUITINGWinston-Salem, North Carolina, 27103, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ambros Clinical Trial Site
RECRUITINGHouston, Texas, 77079, United States
Contact Email: •••••@•••••