Could a ZAP to the brain ease chronic pain? new trial tests personalized stimulation

NCT ID NCT07432841

Recruiting now Symptom relief Sponsor: Istituti Clinici Scientifici Maugeri SpA Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a non-invasive brain stimulation technique called HD-tDCS for people with chronic pain that hasn't improved with other treatments. 144 participants will be randomly assigned to receive either real (anodal or cathodal) or sham (placebo) stimulation over five sessions in one week. The goal is to see if personalized targeting of a brain region involved in pain processing can reduce pain and improve daily functioning, with follow-ups at 3 weeks and 3 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: High-Definition transcranial Direct Current Stimulation (HD-tDCS)
What this could lead to: If it works, this could offer a non-drug option to reduce chronic pain by targeting specific brain areas with personalized stimulation.
What could go wrong: This is an early-phase study with only 144 participants. The effect may be small or temporary, and not everyone may benefit. Risks include mild discomfort or skin irritation from the electrodes.

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC PAIN

Contacts and locations

Locations

Irccs Ismett
RECRUITING

Palermo, 90127, Italy
Istituti Clinici Scientifici Maugeri Spa Società Benefit
RECRUITING

Pavia, 27100, Italy
University of Milano-Bicocca
RECRUITING

Milan, 20126, Italy
University of Palermo
RECRUITING

Palermo, 90127, Italy

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