Magic mushroom compound could ease fibromyalgia pain

NCT ID NCT06368492

Recruiting now Symptom relief Sponsor: Maastricht University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether low doses of psilocybin, the active ingredient in magic mushrooms, can reduce pain in people with fibromyalgia. Thirty-five adults will receive a placebo and two different low doses on separate days. Researchers will measure pain tolerance and self-reported pain to see if psilocybin helps.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: psilocybin
What this could lead to: If it works, this could point toward a new way to manage fibromyalgia pain without strong side effects.
What could go wrong: This is a small, early-phase trial with only 35 people. The low doses may not work, and results might not apply to everyone with fibromyalgia.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Chronic Pain fibromyalgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FIBROMYALGIA

Contacts and locations

Locations

Leiden University Medical Center
RECRUITING

Leiden, South Holland, 2333, Netherlands
Maastricht University
RECRUITING

Maastricht, Limburg, 6226AK, Netherlands

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