Karolinska Institutet

This early-stage trial tested a new DNA vaccine called N-pVAX1 against Crimean-Congo hemorrhagic fever (CCHF), a severe viral disease. Fifteen healthy adults received three doses of the vaccine over 12 weeks. The main goal was to check safety and side effects, while also measurin…

This study tested an online self-management program designed to help people with multiple sclerosis prevent falls. The program was developed with input from patients and covers various fall risk factors. 45 adults with MS participated to see if the program was easy to use and hel…

This study tested whether having a dental assistant visit older adults at home every three months for professional cleaning and high-fluoride toothpaste could prevent root cavities. 194 home-living adults aged 65+ who needed daily care took part. The goal was to see if this appro…

This study tests a specially adapted form of cognitive behavioral therapy for insomnia (CBT-i) in people with bipolar disorder who have sleep problems. The therapy includes sleep scheduling, light exposure, and relaxation techniques. Researchers want to see if it improves sleep q…

This study tested an online version of Parent-Child Interaction Therapy for parents of children aged 2-7 with disruptive behaviors. Twenty-one parents received a 10-week online program with video coaching sessions. The goal was to see if this approach is feasible and acceptable, …

This study compares two common surgeries for thumb arthritis: total joint replacement (arthroplasty) and trapeziectomy (removing a small bone). Researchers will analyze data from 1,000 patients aged 45 and older in a Swedish registry, tracking pain, function, and complications fo…

This study tested a digital group program called 'Fewer Falls in MS' for people with multiple sclerosis who had fallen in the past year. 240 participants either joined the 8-session online program or received a brochure. Researchers tracked falls and other outcomes over 12 months…

This study tested if listening to hypnotherapy audio files can help children and teens with stomach pain and bowel problems linked to stress. 32 participants used the audio treatment at home. The goal was to see if this approach is practical and effective, potentially offering a …

This study looked at how spinal manipulation and stretching affect heart rate and pain sensitivity in 131 adults with long-term neck pain. Participants were randomly assigned to receive either spinal manipulation plus stretching or stretching alone. The goal was to see if these t…

This study tested whether an online reading game called Grapholearn helps Swedish children with developmental language disorder (DLD) improve their reading skills. 67 children played the game for 5 weeks, and their progress was compared to children who played a math game or atten…

This study tested a culturally adapted internet-based cognitive behavioral therapy (iCBT) program for Arabic-speaking refugee and migrant youth aged 15–29 with mild to moderate mental health problems like depression, anxiety, and insomnia. 125 participants were randomly assigned …

This study tested whether internet-based cognitive behavior therapy (CBT) can help people with stress-related disorders like adjustment disorder and exhaustion. 300 adults in Sweden received either online CBT or standard care over 12 weeks. The goal was to see if online therapy r…

This study tested two early interventions for people with stress-related health problems: a nurse-led collaborative care program and therapist-guided self-help CBT. 172 primary care patients took part. The goal was to see if the simpler nurse approach works as well as CBT, which …

This study tested whether a daily breathing exercise program can help people with long COVID who have weak respiratory muscles. 44 adults with long COVID and reduced inspiratory muscle strength were randomly assigned to either breathing exercises plus physical exercise, or physic…

This study tested whether scented nose plugs could make smell training more effective for people who lost their sense of smell after a virus like COVID-19. 120 adults with reduced smell were split into two groups: one did regular smell training at home, and the other used scented…

This study looked at how well a new dialysis solution works compared to the usual one in people with kidney failure who are on peritoneal dialysis. Seven stable patients each tried both solutions during a single 4-hour session. The goal was to measure fluid removal and changes in…

This small study tested whether adding exercise (stationary biking) to standard sensory training could improve sensation and reduce pain after nerve injuries in the arm or hand. Seven adults who had a nerve injury between 2010 and 2025 took part. The goal was to see if this appro…

This study looked at 70,000 adults who had major non-cardiac surgery to see if taking statins before surgery affected their chances of survival and how quickly they recovered at home. Researchers tracked deaths within 30 days and one year, as well as days spent at home after surg…

This completed study looked at nearly 7,000 adults with inflammatory joint diseases like rheumatoid arthritis and psoriatic arthritis. Researchers compared two versions of a standard health survey (EQ-5D-3L and EQ-5D-5L) to see which one better measures health and quality of life…

This completed observational study from Karolinska Institutet looked at 312 children and teens with obesity who used a digital treatment tool called Evira at home. Researchers checked their medical records to see if any developed signs of disordered eating or were diagnosed with …

This study tested a program to help people with stroke or TIA transition from hospital to home. 213 participants received either the program or usual care. The program focused on improving communication, health literacy, and medication management. Researchers measured quality of …

This study worked with 49 stroke patients, their families, and healthcare teams to design and test a more personalized way to move from the hospital to home rehabilitation. The goal was to improve the quality of care transitions and health literacy. The study did not test a treat…

This study tested whether small ventral hernias can be safely repaired under local anesthesia in an outpatient procedure room, rather than a full operating theatre. 37 adults with small hernias were treated, and researchers measured complications, pain, and satisfaction. The goal…

This study looked at how much children with hearing loss and their caregivers understand about what caused the hearing loss. Researchers asked 156 participants to fill out questionnaires about the type and cause of their hearing loss and whether knowing the cause matters to them.…

This study tested an electronic alert system that reminds doctors to screen, monitor, and refer patients with chronic kidney disease (CKD). It involved 66 primary care centers in Stockholm, covering about 780,000 people. The goal was to see if the system improves detection and ma…

This study looked at over 121,000 procedures to remove gallstones from the bile duct using a scope (ERCP). Researchers wanted to see if the level of sedation given during the procedure affected whether stones were left behind. They found that deeper sedation might help the doctor…

This study looked at over 257,000 Swedish men aged 75-79 to see if PSA blood tests for prostate cancer reduce deaths. Since no clinical trials have tested this age group, researchers used existing health records to compare screened and unscreened men. The goal is to find out if s…

This pilot study tested whether using two defibrillators early, instead of one, is feasible and safe for people whose hearts stop outside a hospital and don't respond to the first shock. Researchers enrolled 40 adults with a shockable heart rhythm. The goal was to see if emergenc…

This completed study tested whether a dissolved allergy tablet (Itulazax) can be used as a nasal spray to diagnose birch pollen allergy. 89 participants received either the dissolved tablet or a saltwater spray, and their nasal symptoms and airflow were measured. The goal was to …

This completed study in Cameroon followed 406 adults with and without type 2 diabetes for one year. Researchers tested blood and stool samples at four time points to see if diabetes increases the risk of malaria and other parasitic infections. The goal is to understand how non-co…