Karolinska Institutet

This pilot trial tests two online parenting programs designed for parents who struggle with anger and conflicts with their children. One program teaches standard behavioral parenting strategies, while the other adds emotion regulation techniques to help parents manage their own r…

This trial evaluates PULS, a cognitive behavioral treatment designed to promote prosocial behavior and reduce criminal attitudes, for youth aged 16-21 placed in Swedish institutional care due to criminal involvement. The study compares PULS plus usual care against usual care alon…

This trial tests whether a 12-week group therapy program called Emotion Regulation for Adolescents (ERA) can reduce non-suicidal self-injury in teens aged 13 to 17. Participants must have self-harmed at least five times in the past year, including once in the past month. The prog…

This study tests whether supervised leg exercises can preserve muscle mass in adults with obesity who are starting treatment with incretin-based weight-loss drugs. Participants will train one leg twice a week for 13 weeks, while the other leg serves as a comparison. Researchers w…

This pilot trial tests a new treatment called blended ERITA for adolescents aged 12-17 who have self-injured in the past three months and have low daily functioning. The therapy combines face-to-face sessions with a digital platform, teaching teens skills to manage emotions inste…

This pilot study will test whether a healthy plant-based diet without strict potassium limits is safe for people with advanced chronic kidney disease (stages 4-5). Thirty participants will be assigned to either a liberal plant-based diet or a traditional potassium-restricted diet…

This study tests whether a 10-week psychoeducational health and lifestyle program can help women with Functional Hypothalamic Amenorrhea (FHA) restart their menstrual cycles and improve hormone levels. Seventy women will either take part in the program or receive standard care. R…

This study tests a safety bundle—staff training, checklists, and audits—to prevent surgical site infections after emergency C-sections and open leg fracture repairs in Ethiopia. About 1,000 patients at public hospitals will be followed for 2 years to measure infection rates and d…

This study tests whether a structured program of nutrition advice, physical exercise, brain games, social activities, and health monitoring can improve brain health in adults aged 60 and older who are at risk for memory problems. About 80 participants will either follow the full …

This study will test a family support model that combines two existing programs: a universal school-based program for all first graders and a targeted program for parents of children with overweight or obesity. Researchers will enroll 126 parents of children aged 6-12 in Sweden t…

This study tests whether a digital serious game, Endoexpedition, can improve how people with endometriosis receive information about their condition and treatment options. Participants will be randomly assigned to either play the game or read standard written materials. The trial…

This study tests whether injections of platelet-rich plasma (PRP) can reduce pain and improve jaw function in people with chronic jaw muscle pain (myogenous TMD). Fifty women aged 20–50 with at least 3 months of pain will receive either PRP or a saltwater shot, then be followed f…

This study tests a digital tool called RECapp that helps patients recover after surgery for esophageal or stomach cancer. The app lets patients track symptoms, get personalized self-care advice, and know when to contact their healthcare team. 250 adults in Sweden will use the app…

This study tests a home-based pulmonary rehabilitation program for people with COPD. Participants will follow video-guided exercises, track their daily steps, and receive weekly health coaching. The goal is to improve quality of life, reduce breathlessness, and encourage a more a…

This study compares two ways of giving the sedative propofol during a routine colonoscopy: either the patient pushes a button to self-administer small doses, or a nurse gives the drug as needed. Researchers want to see if self-administration leads to higher patient satisfaction. …

This study tests whether letting patients give themselves sedation medication (propofol) by pressing a button during a colonoscopy leads to higher satisfaction than standard sedation given by a doctor. About 40 adults scheduled for colonoscopy will be randomly assigned to either …

This study tests an 8-week digital program that helps migrants in Sweden improve their mental health through better sleep, diet, physical activity, and social connections. 240 adults with moderate stress, anxiety, or depression will either get the program or a general wellness mo…

This study tests a shortened version of Parent-Child Interaction Therapy (PCIT) that uses videos and 360-degree virtual reality films to help parents manage disruptive behavior in children aged 2-7. Fifteen families will receive up to 10 therapy sessions. Researchers will measure…

This study looks at whether having a special procedure called ERCP available during gallbladder surgery helps reduce complications for people with common bile duct stones. Researchers will review records from 10,000 adults who had gallbladder surgery in Sweden between 2015 and 20…

This study tests a new website designed to help 11-12 year olds and their parents learn about the HPV vaccine. The goal is to see if the tool is easy to use and helpful in real school settings, especially in areas where fewer people get vaccinated. About 100 students and their fa…

This large observational study will follow 4,000 young cancer survivors (ages 15-39) across Europe to understand how different cancer treatments impact fertility, hormone function, and pregnancy outcomes. Researchers will also evaluate the safety and success of fertility preserva…

This study will follow 3,000 young women (ages 15-39) with cancer to understand how treatments like chemotherapy and immunotherapy impact their fertility, pregnancy outcomes, and quality of life. Researchers will also look at the safety and success of fertility preservation metho…

This study follows 1,000 young men (ages 15-39) diagnosed with cancer to understand how treatments affect their fertility and hormone levels over time. Researchers will collect medical history, semen samples, and blood tests before and after therapy to identify who is at risk for…

This study looks at over 500,000 critically ill adults in Swedish ICUs to see if starting continuous kidney dialysis (CRRT) earlier affects how long they stay in the ICU. About 5% of these patients receive CRRT. Researchers will compare early versus late initiation of dialysis an…

This observational study follows 200 patients with colorectal cancer whose liver tumors are found at the same time as the primary cancer. Researchers will compare one-step surgery (removing both tumors at once) versus staged operations (bowel first or liver first) to see which ap…

This study looks at how people with mild intellectual disability process emotions compared to those with autism and typically developing individuals. It also tests a special therapy program to help them regulate emotions. 40 people with intellectual disability will take part in t…

This study will test a device called Q-NRG+ to see if it can accurately measure how much energy critically ill babies under 10 kilograms use. About 80 infants in the pediatric ICU will be observed. The goal is to see if this method works well in very small patients, which could h…

This observational study will look at 400 adults with sepsis and unstable blood pressure to understand how their heart and blood vessels are affected. Researchers will use ultrasound and blood tests to classify patients into different groups based on their heart and blood vessel …

This study aims to find better ways to diagnose bipolar disorder and predict when mood episodes might happen. Researchers will track sleep, activity, and decision-making in 600 people with bipolar disorder, major depression, or healthy controls using smartwatches and computer tas…

This trial will study 2,200 adults with bilateral inguinal hernias (one painful, one not). Half will have both hernias repaired at once, the other half only the painful side. The goal is to compare chronic pain, complications, and the need for future surgery. The study uses Swede…