Karolinska Institutet

This trial tests whether a 12-week group therapy program called Emotion Regulation for Adolescents (ERA) can reduce non-suicidal self-injury in teens aged 13 to 17. Participants must have self-harmed at least five times in the past year, including once in the past month. The prog…

This pilot study will test whether a healthy plant-based diet without strict potassium limits is safe for people with advanced chronic kidney disease (stages 4-5). Thirty participants will be assigned to either a liberal plant-based diet or a traditional potassium-restricted diet…

This phase 3 trial tests whether adjusting tamoxifen doses based on individual metabolism can reduce the number of breast cancer patients who stop treatment early due to side effects. About 1,100 premenopausal or perimenopausal women with hormone-sensitive breast cancer will rece…

This study tests whether a 10-week psychoeducational health and lifestyle program can help women with Functional Hypothalamic Amenorrhea (FHA) restart their menstrual cycles and improve hormone levels. Seventy women will either take part in the program or receive standard care. R…

This study looks at women with breast cancer that has spread to lymph nodes under the arm, found before surgery. Normally, doctors remove many lymph nodes, which can cause arm swelling and pain. The trial tests if removing only the first few affected nodes is just as effective fo…

This study tests a safety bundle—staff training, checklists, and audits—to prevent surgical site infections after emergency C-sections and open leg fracture repairs in Ethiopia. About 1,000 patients at public hospitals will be followed for 2 years to measure infection rates and d…

This study tests whether a structured program of nutrition advice, physical exercise, brain games, social activities, and health monitoring can improve brain health in adults aged 60 and older who are at risk for memory problems. About 80 participants will either follow the full …

This study will test a family support model that combines two existing programs: a universal school-based program for all first graders and a targeted program for parents of children with overweight or obesity. Researchers will enroll 126 parents of children aged 6-12 in Sweden t…

This study tests a home-based pulmonary rehabilitation program for people with COPD. Participants will follow video-guided exercises, track their daily steps, and receive weekly health coaching. The goal is to improve quality of life, reduce breathlessness, and encourage a more a…

This study compares two ways of giving the sedative propofol during a routine colonoscopy: either the patient pushes a button to self-administer small doses, or a nurse gives the drug as needed. Researchers want to see if self-administration leads to higher patient satisfaction. …

This study tests a digital tool called RECapp that helps patients recover after surgery for esophageal or stomach cancer. The app lets patients track symptoms, get personalized self-care advice, and know when to contact their healthcare team. 250 adults in Sweden will use the app…

This study tests whether letting patients give themselves sedation medication (propofol) by pressing a button during a colonoscopy leads to higher satisfaction than standard sedation given by a doctor. About 40 adults scheduled for colonoscopy will be randomly assigned to either …

This study tests whether injections of platelet-rich plasma (PRP) can reduce pain and improve jaw function in people with chronic jaw muscle pain (myogenous TMD). Fifty women aged 20–50 with at least 3 months of pain will receive either PRP or a saltwater shot, then be followed f…

This study tests an 8-week digital program that helps migrants in Sweden improve their mental health through better sleep, diet, physical activity, and social connections. 240 adults with moderate stress, anxiety, or depression will either get the program or a general wellness mo…

This study tests a shortened version of Parent-Child Interaction Therapy (PCIT) that uses videos and 360-degree virtual reality films to help parents manage disruptive behavior in children aged 2-7. Fifteen families will receive up to 10 therapy sessions. Researchers will measure…

This study looks at whether having a special procedure called ERCP available during gallbladder surgery helps reduce complications for people with common bile duct stones. Researchers will review records from 10,000 adults who had gallbladder surgery in Sweden between 2015 and 20…

This study tests a new website designed to help 11-12 year olds and their parents learn about the HPV vaccine. The goal is to see if the tool is easy to use and helpful in real school settings, especially in areas where fewer people get vaccinated. About 100 students and their fa…

This large observational study will follow 4,000 young cancer survivors (ages 15-39) across Europe to understand how different cancer treatments impact fertility, hormone function, and pregnancy outcomes. Researchers will also evaluate the safety and success of fertility preserva…

This study will follow 3,000 young women (ages 15-39) with cancer to understand how treatments like chemotherapy and immunotherapy impact their fertility, pregnancy outcomes, and quality of life. Researchers will also look at the safety and success of fertility preservation metho…

This study follows 1,000 young men (ages 15-39) diagnosed with cancer to understand how treatments affect their fertility and hormone levels over time. Researchers will collect medical history, semen samples, and blood tests before and after therapy to identify who is at risk for…

This study looks at over 500,000 critically ill adults in Swedish ICUs to see if starting continuous kidney dialysis (CRRT) earlier affects how long they stay in the ICU. About 5% of these patients receive CRRT. Researchers will compare early versus late initiation of dialysis an…

This observational study follows 200 patients with colorectal cancer whose liver tumors are found at the same time as the primary cancer. Researchers will compare one-step surgery (removing both tumors at once) versus staged operations (bowel first or liver first) to see which ap…

This study looks at whether a four-session therapy called Brief Cognitive Behaviour Therapy (BCBT) is acceptable and practical for adults hospitalized after a suicide attempt or at high risk. About 32 participants will receive the therapy plus usual care, and researchers will int…

This study looks at how people with mild intellectual disability process emotions compared to those with autism and typically developing individuals. It also tests a special therapy program to help them regulate emotions. 40 people with intellectual disability will take part in t…

This study will test a device called Q-NRG+ to see if it can accurately measure how much energy critically ill babies under 10 kilograms use. About 80 infants in the pediatric ICU will be observed. The goal is to see if this method works well in very small patients, which could h…

This observational study will look at 400 adults with sepsis and unstable blood pressure to understand how their heart and blood vessels are affected. Researchers will use ultrasound and blood tests to classify patients into different groups based on their heart and blood vessel …

This study aims to find better ways to diagnose bipolar disorder and predict when mood episodes might happen. Researchers will track sleep, activity, and decision-making in 600 people with bipolar disorder, major depression, or healthy controls using smartwatches and computer tas…

This study looks at how leg muscle size and strength affect circulation in people born with a single-chamber heart, a condition where the heart can't pump blood to the lungs on its own. Researchers will measure muscle mass, oxygen use, and quality of life in 40 adults aged 16-50 …

This study interviews 30 adults with generalized anxiety, social anxiety, or PTSD who previously completed a trial comparing two therapies: metacognitive therapy (MCT) and cognitive-behavioral therapy (CBT). The goal is to learn what participants thought about each treatment to h…

This trial will study 2,200 adults with bilateral inguinal hernias (one painful, one not). Half will have both hernias repaired at once, the other half only the painful side. The goal is to compare chronic pain, complications, and the need for future surgery. The study uses Swede…

This study looks at screen habits in children aged 0-5 and their parents, and how child health nurses address screen use. About 300 parents will complete surveys on screen time and digital health services, and nurses will take part in focus groups. The goal is to understand scree…

This study will look at how well a program helps nurses ask parents about family violence during routine child health visits. Researchers will review medical records of 90,000 parents and interview nurses to see if the program works and what challenges remain. The goal is to lear…

This study will review medical records of 500 people in Sweden who had contact with psychiatric care and later underwent a forensic psychiatric evaluation after committing a crime. Researchers will look for 26 predefined risk markers that might have appeared before the offense. T…