Karolinska Institutet

This study tests whether giving young children (ages 0.5-3 years) a daily powder containing small amounts of 10 common allergens (like egg, milk, and peanut) can cure their food allergies. About 80 children with confirmed allergies will receive either the allergen powder or a pla…

This trial tests whether scoliosis-specific exercises can stop mild spinal curves from getting worse in children and teens. Participants with mild idiopathic scoliosis will either perform daily self-corrective exercises or just follow standard observation. The study tracks how ma…

This trial compares a 3D-designed Boston brace with the standard Boston brace in 170 teens with idiopathic scoliosis, a spinal curve affecting about 3% of children. Participants wear the brace 20 hours a day until they reach skeletal maturity. Researchers measure whether the 3D b…

This trial tests whether an internet-based form of cognitive behavior therapy (CBT) can reduce symptoms of common mental disorders like anxiety, depression, and stress-related conditions in adults seeking primary care. About 500 participants will be randomly assigned to either th…

This study looks at women with breast cancer that has spread to lymph nodes under the arm, found before surgery. Normally, doctors remove many lymph nodes, which can cause arm swelling and pain. The trial tests if removing only the first few affected nodes is just as effective fo…

This trial tests a 9-month program for women who had preeclampsia during their first pregnancy. The program includes online screening, group meetings, and a smartphone app to help monitor blood pressure and weight. Researchers want to see if it improves heart health and promotes …

This phase 3 trial tests whether adjusting tamoxifen doses based on individual metabolism can reduce the number of breast cancer patients who stop treatment early due to side effects. About 1,100 premenopausal or perimenopausal women with hormone-sensitive breast cancer will rece…

This trial tests whether a smartphone app called SPARK can help women with gestational diabetes manage their condition. Participants receive standard care, and some also use the app to support healthy eating, physical activity, and blood sugar tracking. The study looks at blood s…

This trial tests whether a smartphone app, paired with a wireless spirometer, can help people with asthma or COPD use their inhalers correctly. Participants are randomly assigned to either standard inhaler education or app-based training that measures their inhalation flow and pr…

This trial asks whether robot-assisted hysterectomy is as effective as traditional open surgery for treating early-stage cervical cancer. About 800 women with stage IB (excluding IB3) or IIA1 cervical cancer will be randomly assigned to one of the two surgical approaches. The mai…

This trial asks whether routinely taking an X-ray of the bile ducts during gallbladder removal is better than only doing it when there's a concern. It includes 6,000 patients having gallbladder surgery who have no signs of bile duct stones. The goal is to see which approach leads…

This trial compares two surgical techniques for treating a painful jaw condition called disc displacement without reduction, where the jaw's cushioning disc slips out of place and limits mouth opening. Participants will receive either arthroscopic lysis and lavage, a procedure th…

This trial compares two arthroscopic procedures for treating painful jaw joint disc displacement with reduction. One procedure involves rinsing the joint and releasing adhesions, while the other adds further tissue adjustment. The study will see which method better improves mouth…

This study tests whether botulinum toxin (Botox) injections into the jaw muscle can reduce pain and alter pain-related gene activity in people with painful jaw disorders. Half of the 100 participants receive Botox, the other half a placebo (saline). Researchers compare pain level…

This study tests a dog allergy immunotherapy called Alutard SQ Dog in 40 adults with moderate-to-severe dog allergy. Participants receive increasing doses over 13 weeks, then maintenance shots every 6-8 weeks for a year. Their symptoms and lung function are measured before and af…

This study tests whether a lifestyle program can help people with obsessive-compulsive disorder (OCD) become more active and lower their risk for heart disease and diabetes. Researchers will enroll 108 adults with OCD who are not very active. The program focuses on increasing dai…

This study compares two types of CPR for people who have a cardiac arrest outside a hospital: hands-only CPR (chest compressions without rescue breaths) versus standard CPR (compressions plus rescue breaths). The trial will include over 3,000 adults whose cardiac arrest is witnes…

This study tests whether adding a digital behavioral tool called Evira to standard obesity medication (liraglutide or semaglutide) helps teens with obesity lose more weight than medication alone. Forty adolescents aged 12-17 will be randomly assigned to either the combination or …

This trial tests a therapy called SAFETY, designed to help teenagers who have recently attempted suicide. The study will include 282 youths aged 10-17 and their caregivers. Half will receive SAFETY, a family-based cognitive-behavioral program, and the other half will get enhanced…

This study is testing whether people with displaced hand fractures can avoid surgery and instead use early, unrestricted movement and rehabilitation. 552 adults with a single displaced spiral or oblique fracture of the index to pinky finger bones will be randomly assigned to eith…

This study tests a stepped care approach for children aged 8-16 who struggle with anger, defiance, or aggression. All families start with a brief online parenting program. If more help is needed, they are randomly assigned to additional options, including virtual reality-assisted…

This pilot study tests whether the drug eplerenone is safe and feasible for people with both heart failure (reduced pumping ability) and severe chronic kidney disease. Previous studies excluded such patients due to risks like high potassium. The trial will enroll 40 participants …

This study tests whether adding stair climbing to a brisk walking routine lowers blood pressure more than walking alone. 450 adults with high blood pressure, overweight, and a sedentary lifestyle will be split into three groups: stair walking plus brisk walking, brisk walking onl…

This study compares two approaches for women under 39 with advanced endometriosis who want to get pregnant: having surgery to remove endometriosis lesions before IVF, or going straight to IVF. The goal is to see which leads to more live births within three years. The trial will e…

This study tests a digital support system called Evira for treating childhood obesity. Children weigh themselves daily at home using a special scale that sends data to an app on their parent's phone and to the clinic. The goal is to see if adding this system to standard lifestyle…

This study tests whether cooling the brain quickly after a cardiac arrest (using a special nasal device) and then keeping the body cool for 24 hours helps more people survive with full brain function. About 1,000 adults aged 18-79 who have a shockable heart rhythm will be randoml…

This trial tests whether supervised exercise during chemotherapy can help eliminate breast cancer more effectively. 712 participants will be randomly assigned to either a structured exercise program or usual care. The main goal is to see if exercise increases the rate of complete…

This study tests whether replacing the arthritic thumb base joint with a dual-mobility implant provides better pain relief during activity than standard non-implant surgeries. 90 participants will receive the implant and be compared to 90 similar patients from an earlier trial. R…

This study tests whether allowing patients with severe psychiatric conditions to admit themselves to inpatient care (up to 4 days at a time, 3 times per month) can reduce involuntary admissions and improve quality of life. Over 500 participants in Stockholm will be followed, comp…

This study compares two common surgical grafts used to repair a torn anterior cruciate ligament (ACL): the semitendinosus hamstring tendon and the quadriceps tendon-bone graft. Researchers will enroll 200 active adults who recently tore their ACL and plan to return to sports. The…

This study is testing whether a blood test that measures donor DNA can detect rejection in heart transplant patients. Researchers will compare the test results with standard heart biopsies in 120 adults across Sweden. If the test works well, it could offer a less invasive way to …

This study tests a digital lifestyle program for adults aged 40-60 in Swedish primary care. Participants receive standard health advice plus app-based support for diet, exercise, alcohol, and smoking. The goal is to see if the program improves cholesterol and other heart health m…

This study tests an online, therapist-guided program to help cancer survivors who have anxiety, depression, or fear of cancer returning. About 400 adults in Sweden who finished cancer treatment at least 6 months ago will take part. The goal is to see which parts of the 10-week on…

This pilot study tests a psychological treatment called Pain Reprocessing Therapy (PRT) for people with chronic pain lasting more than three months. PRT teaches patients to understand how the brain processes pain signals and to change their response to pain, with the goal of redu…

This trial tests whether an internet-based cognitive behavior therapy (CBT) program can reduce symptoms of anxiety, depression, and stress in adults with mild mental health issues who visit primary care. Participants are randomly assigned to either the online CBT program, which i…

This study tests a new anonymous online therapy program called Restory for people with PTSD after sexual abuse. It is designed for 140 adults who have experienced sexual violence at least one month ago. The therapy uses a type of talk therapy done over the internet, and the goal …

This study tests a group-based program called GEARS that teaches emotion regulation skills to adults with ADHD. Researchers will compare 150 participants who receive GEARS to those on a waiting list, measuring changes in emotional control, ADHD symptoms, and quality of life. The …

This study tests whether doing yoga-based exercises once a week for 8-12 weeks can reduce headache frequency and improve sleep and quality of life in people with chronic migraine or cluster headache. Participants can join online or in person. The goal is to see if yoga can be a h…

This study tests an internet-based therapy called IERITA for teenagers aged 13-17 who have hurt themselves on purpose. The therapy teaches emotion regulation skills through online modules and therapist support. The goal is to see if this approach can help teens stop self-injuring…

This study is testing a support program for teens and young adults (ages 16-30) who have just been diagnosed with cancer. The program includes a meeting with a special team and a structured course called PRISM that teaches skills like stress management and goal setting. About 130…

This study compares two ways of giving a lung-opening medicine (surfactant) to premature babies with breathing problems. The newer method uses a soft mask placed in the throat instead of a breathing tube down the windpipe. Researchers want to see if the gentler method works just …

This study tests whether a therapist-guided online cognitive-behavior therapy program can help reduce obsessive-compulsive disorder (OCD) symptoms in children and teens with autism. About 220 participants will receive the online treatment or a comparison condition. The goal is to…

This study tests whether a therapist-guided online cognitive-behavioral therapy (CBT) program can reduce symptoms of body dysmorphic disorder (BDD) in children and teens aged 12-18. About 154 participants will receive the online treatment or a control, with follow-up at 6 months.…

This study tests whether a 5-day intensive version of prolonged exposure therapy can treat PTSD as effectively as the standard 15-week approach. 140 adults with PTSD will be randomly assigned to either the intensive format or weekly sessions. Researchers will also look at cost-ef…

This study tests whether a newer type of talk therapy called transdiagnostic metacognitive therapy (tMCT) works better than standard cognitive-behavioral therapy (CBT) for people with generalized anxiety, social anxiety, or PTSD. About 86 adults in Sweden will receive either tMCT…

This study looks at whether a type of talking therapy (cognitive behavioral therapy) can help reduce severe fatigue in primary care patients. About 190 adults aged 18-67 with long-lasting fatigue will either get the therapy or usual care. The goal is to see if the therapy improve…

This study tests two digital treatments for children aged 8-17 with chronic stomach pain caused by gut-brain interaction disorders. After a 4-week online education program, participants are randomly assigned to either internet-based cognitive behavioral therapy (iCBT) or gut-dire…

This study compares a new type of therapy that combines computer exercises with therapist sessions (blended CBT) to standard prolonged exposure therapy for PTSD. About 160 adults with PTSD will receive one of the two treatments at outpatient clinics in Sweden. The goal is to see …

This study is testing whether a type of talk therapy called metacognitive therapy (MCT) can be delivered in a group setting for people with post-traumatic stress disorder (PTSD) in regular psychiatric care. The goal is to see if it is practical and acceptable to patients, and to …

Up to 25% of pregnant women experience mental health issues like depression and anxiety. This trial tests a mobile app called HealthyMoms4MentalHealth designed to promote psychological wellbeing during pregnancy. Researchers will enroll 440 pregnant women in Sweden and measure ch…

This study looks back at medical records of 150 children who had cleft palate surgery. Some received standard pain relief with morphine, while others also got a maxillary nerve block. Researchers want to see if the nerve block group needed less morphine, had fewer side effects, a…

This study tests a culturally and language-adapted internet-based cognitive behavioral therapy (i-CBT) for Farsi/Dari-speaking youth migrants and refugees aged 15-29. The goal is to reduce symptoms of common mental health problems like anxiety, depression, and stress. Participant…

This study looks at whether giving people with generalized anxiety disorder the power to choose between two internet-based treatments helps them feel better and stick with the program. About 440 adults will either pick their preferred therapy or be assigned one randomly. The goal…

This pilot study tests whether a 5-day intensive therapy program can help teens aged 13–17 with PTSD. The program combines trauma-focused therapy, EMDR, physical activity, and parent support. Researchers want to see if it's practical and acceptable in Swedish child psychiatry, an…

This study tests an online program called POET that teaches teens aged 12-17 how to understand and regulate their emotions. The goal is to reduce mental health symptoms like anxiety and depression. The trial will include 388 participants and follow them for up to 10 years to see …

This study tests whether an online cognitive behavioral therapy (CBT) program can reduce heart-related anxiety in people who have had a heart attack or unstable angina. 176 participants will be randomly assigned to either the CBT program or a digital lifestyle advice group. The g…

This study asks whether intensive care doctors are unconsciously biased by a patient's gender or ethnicity when deciding to admit them to the ICU. Researchers will send out thousands of identical patient case descriptions, changing only the sex or a name that suggests a particula…

This study will review medical records of 500 people in Sweden who had contact with psychiatric care and later underwent a forensic psychiatric evaluation after committing a crime. Researchers will look for 26 predefined risk markers that might have appeared before the offense. T…

This study interviews 30 adults with generalized anxiety, social anxiety, or PTSD who previously completed a trial comparing two therapies: metacognitive therapy (MCT) and cognitive-behavioral therapy (CBT). The goal is to learn what participants thought about each treatment to h…

This study looks at whether a four-session therapy called Brief Cognitive Behaviour Therapy (BCBT) is acceptable and practical for adults hospitalized after a suicide attempt or at high risk. About 32 participants will receive the therapy plus usual care, and researchers will int…

This study looks at whether scheduling workouts based on menstrual cycle phases improves fitness in women who exercise regularly. About 111 female athletes will follow different training schedules over three cycles. Researchers will measure changes in aerobic fitness, muscle stre…

This study will follow 50,000 adults having planned non-cardiac surgery at two hospitals in Sweden. Researchers want to see if how much physical activity people report doing before surgery can help predict complications like infections, heart problems, or death. The goal is to fi…

This study gathers detailed information from thousands of patients across Nordic countries and the Netherlands who have acute type A aortic dissection, a rare and life-threatening tear in the aorta. Researchers will track patients' health before surgery, the surgical procedure th…

This study follows 130 adults undergoing surgery for stomach or esophageal cancer to see how often they experience postoperative delirium—a state of confusion and disorientation after anesthesia. Researchers will also check whether depression, frailty, poor nutrition, or muscle l…

This study follows 91 people who had jaw joint surgery (arthroscopy or disc removal) about 10 years ago. Researchers want to see if the improvements seen at 6 months still hold up over the long term, and how the joint changes on X-rays over time. The goal is to understand how sta…

This study looks at whether the proteins in the saliva of 3-year-old children can help predict their risk of developing early childhood caries (cavities). Researchers will compare saliva samples and dental exams from children in two different communities in Stockholm, Sweden, to …

This study aims to gather crucial information about stroke in Uganda, where the disease is on the rise. Researchers will look at how common stroke is, what factors increase the risk, and how it affects people's quality of life. The goal is to identify what rehabilitation support …

This study compares carbon dioxide emissions from orthopedic surgeries performed with different materials and setups. Researchers will track waste, energy use, and sterilization methods for procedures like carpal tunnel release or wound revision. The goal is to identify ways to r…

This study looks at how much pollution and waste come from two ways of treating certain hand fractures: surgery or just letting the bone heal naturally with a splint or tape. Researchers will track 30 adults for a year, measuring things like carbon emissions and trash. The goal i…

This observational study is recruiting 600 participants to improve detection and understanding of dementia with Lewy bodies (DLB). Researchers will collect clinical data, brain scans, and spinal fluid samples from people with early symptoms like hallucinations or movement problem…

This study looks at how stroke changes the way the brain handles walking while doing another task, like listening or navigating. Researchers will monitor brain activity in 50 stroke survivors as they walk on different paths and respond to sounds. The goal is to better understand …

This study tests whether keeping the thumb in a cast for four weeks after surgery reduces the risk of tendon rupture compared to the standard early active motion therapy. About 380 patients in Sweden will be randomly assigned to one of the two rehab programs. The goal is to find …

This study looks at how 14 days of simulated microgravity (using a leg suspension model) changes the brain's movement programs and muscle control. Twenty-four healthy adults will have one leg unloaded while using crutches, then walk on a treadmill in lunar gravity during a parabo…

This study is testing a screening tool called Start-MSK that helps physiotherapists sort people with muscle or joint pain into low, medium, or high risk for long-term problems. Researchers will follow 300 adults for 6 months to see if the tool can predict who will recover well an…

This study follows 450 people with Parkinson's disease for four years to learn why some become less active and what helps them stay active. Participants wear activity monitors and complete tests and questionnaires. The goal is to identify early warning signs of declining activity…

This study looks at how the natural microbes and chemical profiles in couples' bodies relate to IVF outcomes. Researchers will collect samples from 1000 couples and track whether they have a baby, miscarriage, or other pregnancy results. The goal is to find patterns that might he…

This study tracks 80 children under 18 with a tracheostomy who need anesthesia for a routine airway exam. Researchers want to find out how often serious complications happen and if certain factors like age or ventilator use raise the risk. The goal is to gather data to make anest…

This study tests whether beetroot juice, which contains natural nitrates that relax blood vessels, can safely lower lung blood pressure in people with intermediate high-risk pulmonary embolism. 36 adult patients will receive either beetroot juice or a placebo for five days, along…

This study looks at children with tracheostomies to see if serious airway problems can be spotted early by symptoms parents or doctors notice. Researchers will compare these symptoms with what a camera inside the airway (endoscopy) finds. The goal is to understand how reliable sy…

This observational study looks at children under 18 who have a tracheostomy (a breathing tube in the windpipe). Researchers want to find out how common feeding difficulties are in these children and whether those difficulties are linked to their quality of life. The study will in…

This study looks at whether putting fruit stands in schools helps students eat more fruit, and if adding a health-awareness campaign makes a bigger difference. About 300 Swedish students aged 7 to 19 will use a phone app to take pictures of their meals and snacks. The goal is to …

This study compares Advanced Trauma Life Support (ATLS) training for doctors against usual care to see if it improves survival in adult trauma patients. Over 4,000 patients from hospitals in India will take part. The goal is to find out if this widely used training actually saves…

This study tests a method called Feedback Informed Treatment (FIT) in Swedish social services. Social workers will regularly ask clients for feedback using simple rating scales, then adjust support based on what clients say. The goal is to see if this reduces dropout and helps pe…

This study explores whether a simple at-home HPV test can help women in war-torn Ukraine get screened for cervical cancer. About 1,000 women aged 30-60 who haven't had a recent negative HPV test will receive a self-sampling kit. The goal is to see if this approach is practical an…

This study looks at the best way to treat nerve injuries in the fingers. It compares surgery with wearing a cast. About 166 adults with a cut nerve in one finger will be randomly assigned to one of the two treatments. The main goal is to see how well feeling returns after one yea…

This study looks at whether a campaign called Choosing Wisely can safely reduce unnecessary tests and treatments in intensive care units (ICUs). About 10,000 adult patients in Swedish ICUs will take part. The goal is to see if this approach lowers costs and improves care without …

This observational study looks at how bacteria in the gut and mouth are linked to epilepsy and whether they affect how well seizure medicines work. Researchers will collect stool, saliva, and blood samples from 1,500 people with newly diagnosed epilepsy and healthy controls. By a…

This study looks at 300,000 surgical patients in Stockholm to see how the COVID-19 pandemic impacted their recovery. Researchers will track deaths, complications, and how long people stayed in the hospital. The goal is to understand the pandemic's effects on surgical care, not to…

This study tests whether using computer models to personalize tuberculosis (TB) drug doses can help patients reach optimal drug levels faster. Researchers will monitor 30 adults with pulmonary TB who are already on standard treatment. The goal is to see if this approach helps doc…

This study compares two approaches after robotic hysterectomy: going home the same day versus staying overnight in the hospital. Researchers will track quality of life and complications over 30 days in 300 patients with benign conditions or endometrial cancer. The goal is to see …

This study is testing whether brain scans can predict how well people respond to internet-based cognitive behavioral therapy (iCBT) for depression, insomnia, and social anxiety. Researchers will scan the brains of 150 participants before they start 12 weeks of online therapy. The…

This study looks at how weight loss changes the way people with advanced cancer feel about their bodies. Researchers will survey 800 participants from different countries to understand differences related to gender and location. The goal is to create better, fairer nutrition advi…

This study will follow 90 people with mitral valve prolapse who are already scheduled for mitral valve surgery. Researchers will use heart scans and 7-day rhythm monitors before and 6 months after surgery to see if the procedure reduces dangerous heart rhythms and scarring. The g…

This study aims to objectively measure how internet-based exposure-based cognitive behavioral therapy (Exp-CBT) affects pain regulation in people with fibromyalgia. About 45 participants will undergo pain tests before and after 10 weeks of online therapy to see if their pain thre…

This observational study will compare blood and tissue samples from 40 diabetic patients with foot ulcers. Researchers want to understand how immune cells differ between people whose ulcers heal and those whose ulcers do not. The goal is to identify specific immune cell patterns …

This study looks at whether doing a repeat kidney biopsy one year after starting treatment for lupus nephritis can help doctors decide if more treatment is needed. Half of the 206 participants will get the repeat biopsy, and the other half will follow standard care. The goal is t…

This study investigates how red blood cells influence heart attack risk in people with type 2 diabetes. Researchers will collect blood from 500 participants (patients with heart attacks, type 2 diabetes, and healthy volunteers) and test the cells in the lab to understand their ef…

This study looks at whether the number of steps people take each day (tracked by their phone) is linked to how well they recover after non-cardiac surgery. Researchers will follow 264 adults and measure days spent at home alive within 30 days after surgery. The goal is to see if …

This study is testing new blood tests to see if they can better measure how well bleeding treatments work in people with haemophilia who have developed inhibitors (antibodies that block standard treatment). The researchers will take blood samples from 20 patients before and after…