Botox for jaw pain: a shot at rewiring pain signals?
NCT ID NCT05720065
First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time
Summary
This study tests whether botulinum toxin (Botox) injections into the jaw muscle can reduce pain and alter pain-related gene activity in people with painful jaw disorders. Half of the 100 participants receive Botox, the other half a placebo (saline). Researchers compare pain levels and muscle tissue samples before and after treatment to see if Botox changes how pain signals are processed.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Botulinum toxin type A (Botox) injections
- What this could lead to
- If it works, this could point toward a new way to treat jaw muscle pain by targeting pain signals at the source.
- What could go wrong
- This is a mid-stage trial, so results may not hold up in larger studies. Botulinum toxin injections can cause temporary muscle weakness or discomfort.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department of Dental Medicine, Karolinska Institutet
RECRUITINGHuddinge, Stockholm County, SE14104, Sweden
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