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Retraining the brain to turn down chronic pain: a new therapy put to the test

NCT ID NCT07791355

Symptom relief Sponsor: Karolinska Institutet Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time

Summary

This pilot study tests a psychological treatment called Pain Reprocessing Therapy (PRT) for people with chronic pain lasting more than three months. PRT teaches patients to understand how the brain processes pain signals and to change their response to pain, with the goal of reducing fear and disability. The study includes 25 adults in a Swedish pain rehabilitation setting and will check if the therapy is practical and acceptable, as well as whether it helps reduce pain and psychological distress.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Pain Reprocessing Therapy (PRT), a 9-week behavioral intervention with individual and group sessions
What this could lead to
If PRT proves practical and effective, it could offer a new non-drug treatment for chronic pain that helps people reduce fear and disability.
What could go wrong
This is a small pilot study, so results may not apply broadly. PRT may not work for everyone, and the therapy requires time and commitment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 25 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years and older. * Completed medical investigation regarding the pain diagnosis. Primary pain conditions (according to ICD-11) or nociplastic pain, as well as mixed conditions where patients have nociplastic pain combined with nociceptive and/or neuropathic pain (e.g., fibromyalgia, chronic widespread pain, primary chronic back pain). * Pain duration of at least 3 months. * Current medication regimen compatible with participating in and benefiting from highly specialized rehabilitation. * Ability to read, speak, and understand the Swedish language. * Exclusion Criteria: * Severe psychiatric conditions (e.g., psychosis, severe depression, and suicidality). * Current substance abuse (including overuse of prescription medications) or dementia. * Cancer pain, cauda equina syndrome, or other medical conditions that constitute the primary explanation for the patient's pain. * Another psychological treatment for pain within the past 3 months. * Ongoing parallel treatments related to the patient's pain at other clinics, with the exception of ongoing pharmacological treatment. * Ongoing legal disputes or active claims for disability compensation.

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic pain

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Karolinska Institutet

    RECRUITING

    Stockholm, Sweden

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