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Could a blast of cold air save your brain after a heart attack?

NCT ID NCT06025123

Disease control Sponsor: Karolinska Institutet Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether cooling the brain quickly after a cardiac arrest (using a special nasal device) and then keeping the body cool for 24 hours helps more people survive with full brain function. About 1,000 adults aged 18-79 who have a shockable heart rhythm will be randomly assigned to either rapid cooling or standard care. The main goal is to see if more people in the cooling group are alive and neurologically healthy 90 days later.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 1,022 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2024

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 79 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

INCLUSION CRITERIA: Patients ≥18 years that meet all of the following inclusion criteria: 1. Adult out-of-hospital cardiac arrest patients with initial shockable rhythm 2. Unconsciousness defined as Glasgow Coma Scale \< 8 3. Inclusion within 20 minutes from EMS arrival EXCLUSION CRITERIA: Patients are not eligible if they meet one or more of the following criteria: 1. Age ≥ 80 years 2. Obvious non-cardiac causes to cardiac arrest 3. Obvious already hypothermic 4. Obvious barrier to placing intra nasal catheters 5. Have a known Do Not Attempt to Resuscitate (DNAR) order or other limitations in care 6. Have a known terminal disease 7. Known or clinically apparent pregnancy

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Conditions

The condition(s) this trial relates to.

cardiac arrest Hypothermia Out-of-Hospital Cardiac Arrest ventricular fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypothermia Out-of-hospital cardiac arrest Ventricular fibrillation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    11 sites in 7 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CHU Saint-Pierre

    RECRUITING

    Brussels, Belgium

  • Department of Anesthesiology, Intensive Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

    NOT_YET_RECRUITING

    Milan, Italy

  • Erasme University Hospital

    RECRUITING

    Brussels, Belgium

  • Europe Hospitals St Elizabeth

    RECRUITING

    Brussels, Belgium

  • Hospital Universitario La Paz

    RECRUITING

    Madrid, Spain

  • Karolinska University Hospital

    RECRUITING

    Stockholm, Sweden

  • Ljubljana University Medical Centre

    RECRUITING

    Ljubljana, Slovenia

  • San Carlos Clinical Hospital

    RECRUITING

    Madrid, Spain

  • Södersjukhuset

    RECRUITING

    Stockholm, Sweden

  • University Hospital Freiburg

    RECRUITING

    Freiburg im Breisgau, Germany

  • University Hospital Vienna

    NOT_YET_RECRUITING

    Vienna, Austria

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