OUT-OF-HOSPITAL CARDIAC ARREST

This study tests a new way to restart the heart in people who have a cardiac arrest outside the hospital and don't respond to the first shock. It compares using two defibrillators in different positions versus the standard single defibrillator. The goal is to see if the double ap…

This study tests if cooling people quickly after a cardiac arrest (when the heart stops) can help them survive with full brain function. About 1,022 adults aged 18-79 who have a shockable heart rhythm will be included. Half will get rapid cooling through the nose by emergency wor…

This study looks at whether giving a combination of three drugs (epinephrine, vasopressin, and a steroid) to adults who suffer a sudden cardiac arrest outside the hospital can restart their heart better than the standard single drug (epinephrine). About 1,344 participants will be…

This study tests whether repeatedly inflating and deflating a blood pressure cuff on a patient's leg soon after a cardiac arrest can reduce brain damage. The approach, called remote ischemic post-conditioning (RIPOST), aims to protect the brain from injury caused by blood flow re…

This study looks at whether placing a balloon in the main artery (aorta) during CPR can help blood flow to the heart and brain in people who have a cardiac arrest outside the hospital. It involves 40 adults aged 18-80 with no major injuries. The goal is to see if the procedure is…

This study is a registry that will collect detailed information from 400 people who had a cardiac arrest outside of a hospital due to a heart problem. The goal is to track their treatment and recovery to find ways to improve survival and quality of life. No new treatments are bei…

This study explores using drones to quickly deliver automated external defibrillators (AEDs) to people helping someone in cardiac arrest outside a hospital. Researchers will test the drone delivery process with training manikins and interview people with and without cardiac arres…

This study follows 3,500 adults who survived a cardiac arrest to see how different hospital treatments (sedation, temperature control, and blood pressure management) impact their kidneys. Researchers will measure kidney failure, need for dialysis, and long-term kidney function. T…

This study looks at rules used by emergency workers to decide when to stop trying to restart a person's heart after a cardiac arrest outside a hospital. These rules were made in Western countries, and researchers want to see if they work well for people in Asia. They will study 1…

This study tests whether giving community first responders real-time feedback and video support from dispatchers can improve the quality of CPR they provide during out-of-hospital cardiac arrests. About 165 trained volunteers in Singapore will use either the current system or an …

This study tests whether cooling cardiac arrest patients right after their heart restarts, using a special vest worn in the ambulance, is practical and safe. About 50 adults in Singapore will take part. The goal is to see if this early cooling can be done smoothly by paramedics, …

This study creates a training program using simulation and artificial intelligence to teach junior doctors how to use transesophageal echocardiography (TEE) during cardiac arrest. About 60 emergency physicians will learn and be tested on their skills. The goal is to improve how q…

This study looks at 840 people in Paris whose hearts stopped and did not restart with standard CPR. They received a special machine called ECMO that pumps blood for the body while doctors try to restart the heart. Researchers will check how many survive for one year and how well …

This study compares two ways of doing CPR when someone's heart stops outside a hospital: chest compressions only versus compressions plus rescue breaths. About 3,260 adults with witnessed cardiac arrest will take part, and only bystanders with prior CPR training are included. The…

This study looks at pain in patients who survive a cardiac arrest and are treated in the intensive care unit (ICU). Researchers want to understand how pain is measured and managed, and how it affects recovery, including the risk of delirium. The goal is to improve pain care and h…