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Double shock may save more cardiac arrest victims

NCT ID NCT07174986

Recruiting now Disease control Sponsor: Gabriel Riva Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This trial tests whether using two defibrillators in sequence, instead of the standard single defibrillator, can improve survival in people whose hearts are in a shockable rhythm but don't respond to the first shock. About 916 adults with out-of-hospital cardiac arrest will be randomly assigned to either the double-shock approach or standard care. The main goal is to see if more patients are alive at 30 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Double sequential defibrillation (using two defibrillators)
What this could lead to
If it works, this could become a new standard emergency procedure to save more lives in cardiac arrest.
What could go wrong
This is an early combined Phase 2/3 trial, so results are uncertain. The benefit seen in a prior study may not hold in this broader group.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acrocallosal syndrome cardiac arrest Death, Sudden Out-of-Hospital Cardiac Arrest ventricular fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACLS CPR DEFIBRILLATION OUT-OF-HOSPITAL CARDIAC ARREST SUDDEN DEATH VENTRICULAR FIBRILLATION

Contacts and locations

Locations

  • ARREST (AmsteRdam REsuscitation STudies)

    NOT_YET_RECRUITING

    Amsterdam, Netherlands

  • Ambulanshelikoptern (HEMS) Västra Götalandsregionen

    RECRUITING

    Kungälv, Västra Götaland County, 442 83, Sweden

  • Ambulanssjukvården Region Värmland

    RECRUITING

    Karlstad, Värmland County, 65230, Sweden

  • Ambulanssjukvården Skaraborgs Sjukhus, Västra Götalandsregionen (SKAS)

    RECRUITING

    Skövde, Sweden

  • Ambulanssjukvården, Region Halland

    RECRUITING

    Halmstad, Halland County, Sweden

  • Centro de Emergencias 061 Andalucía

    NOT_YET_RECRUITING

    Málaga, Andalusia, 29560, Spain

  • Emergency medical services NU-Sjukvården, Region Västra Götaland

    RECRUITING

    Trollhättan, 461 85, Sweden

  • Emergency medical services, Södra Älvsborgs Sjukhus, Region Västra Götaland

    RECRUITING

    Borås, 501 82, Sweden

  • Médico Emergencias Osakidetza EMERGENTZIAK

    NOT_YET_RECRUITING

    Bilbao, Baque Country, 48004, Spain

  • Prehospital Intensive Care Unit (PIV) AnOPIVA Östra Sjukhuset/SU

    RECRUITING

    Gothenburg, Sweden

  • SUMMA 112 Emergency medical services

    NOT_YET_RECRUITING

    Madrid, Madrid, 28045, Spain

  • Shalgrenska University Hospital

    RECRUITING

    Gothenburg, Sweden

  • Sistema de Emergencias Medicas de Catalunya

    NOT_YET_RECRUITING

    Barcelona, Catalonia, 08908, Spain

  • Sjukvården i väster

    RECRUITING

    Alingsås, Sweden

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