A needle in the neck to shock the heart back to life?

NCT ID NCT04168970

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This trial tests whether injecting a local anesthetic into a nerve cluster in the neck—called a stellate ganglion block—can help stop dangerous heart rhythms in people who suffer a cardiac arrest outside a hospital. The study includes adults whose heart stops with a shockable rhythm that does not respond to repeated defibrillator shocks. Researchers will measure whether the procedure terminates the abnormal rhythm and restores a normal heartbeat, comparing outcomes to historical cases.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Percutaneous stellate ganglion block: an injection of local anesthetic (lidocaine) into the neck to calm overactive heart nerves during cardiac arrest.
What this could lead to
If effective, this quick nerve-block procedure could become a rescue tool for emergency teams, potentially stopping fatal heart rhythms and saving more lives from cardiac arrest.
What could go wrong
This is a small observational study, so results may not apply broadly. The procedure carries risks like bleeding or nerve damage, and it is unclear if it will improve survival compared to standard care.

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Conditions

The condition(s) this trial relates to.

cardiac arrest Out-of-Hospital Cardiac Arrest ventricular fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Fondazione IRCCS Policlinico San Matteo

    Pavia, Pavia, 27100, Italy

  • Fondazione IRCCS Policlinico San Matteo

    Pavia, PV, 27100, Italy

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