Fondazione Irccs Policlinico San Matteo Di Pavia

This study looks at a non-surgical procedure called renal embolization to shrink enlarged kidneys in 30 dialysis patients with autosomal dominant polycystic kidney disease (ADPKD). The goal is to reduce kidney size enough to allow for a kidney transplant, which is often delayed w…

This study tests whether a heart-lung machine (ECMO) can be used by emergency teams outside the hospital to treat people whose hearts have stopped and won't restart with standard CPR. The goal is to restore blood flow to the brain and body faster, potentially improving survival a…

This study tests whether two food supplements, Cynacol and Metacol, can lower LDL (bad) cholesterol in people with mild high cholesterol. About 40 adults aged 35-70 with LDL levels between 115 and 190 mg/dL will take one supplement daily for 90 days. The goal is to see which supp…

This study is testing whether a supplement called Euglycem, taken alongside a standard diet, can lower fasting blood sugar in people with dysglycemia (abnormal blood sugar levels). About 108 participants will be randomly assigned to receive either Euglycem plus diet advice or die…

This study looks at whether holding your breath deeply during breast cancer radiation can keep the heart safe from radiation damage. About 400 women with early-stage breast cancer will either use a special breathing device or breathe normally during treatment. The goal is to meas…

This study aims to see if a molecular test called PCR can diagnose malaria, leishmania, and pneumocystis infections faster and more accurately than current methods. Researchers will analyze about 200 stored samples from people suspected of having these infections. The goal is to …

This study looks at how well the shingles vaccine works in 300 people with weakened immune systems, such as those with cancer or autoimmune diseases. Researchers will measure immune responses and track side effects after vaccination. The goal is to better protect these vulnerable…

This study looks at whether a protein called BNP, measured in babies and again in teenagers, can help identify teens at risk for metabolic syndrome (a cluster of conditions like obesity, high blood pressure, and diabetes). Researchers will follow 70 adolescents who were part of a…

This study aims to develop a better method for extracting stem cells from umbilical cord blood. Researchers will compare the usual method with a new one that uses a special liquid to separate stem cells gently. They will also test if low-dose ozone can help the stem cells grow be…

This study looks at a specific gene (IGLV1-44) to understand why it causes two rare diseases: AL amyloidosis and POEMS syndrome. Researchers will analyze blood and bone marrow samples from 100 adults with these conditions or multiple myeloma. The goal is to find genetic patterns …

This study looks at whether a special imaging technique (electrical impedance tomography) and lung ultrasound can help doctors predict which premature babies will develop a serious lung condition called bronchopulmonary dysplasia (BPD). The study will include 104 preterm infants …

This study is creating a registry of 520 patients with central nervous system (CNS) infections, such as meningitis and encephalitis. Researchers will track patient outcomes, including survival at discharge, to better understand these rare but serious conditions. No new treatments…

This study looks at how well hip, knee, shoulder, and other joint replacement surgeries work in adults with inherited bleeding disorders like hemophilia. Researchers will collect information from medical records and follow patients over time to understand risks, complications, an…

This study follows 200 women with symptomatic uterine fibroids who are scheduled for either hysterectomy or myomectomy. Researchers will compare pelvic floor symptoms and measurements before and up to 12 months after surgery. The goal is to understand how different surgical treat…

This study is collecting information from 300 people in Italy with advanced non-small cell lung cancer who are receiving a treatment that combines two immunotherapy drugs (nivolumab and ipilimumab) with chemotherapy. The goal is to see how well this treatment works in everyday me…

This study looks at whether a bedside exam done by emergency room doctors can accurately tell if a patient's vertigo, dizziness, or unsteadiness is caused by a stroke or other central nervous system problem. Researchers will study 825 adults in the ER to see how well the exam wor…

This study is for pregnant women who have had a first-time HCMV infection early in pregnancy. Researchers want to find out if certain immune system markers can predict whether the virus will be passed to the baby. They will take blood samples and analyze immune cells, but no new …

This observational study aims to understand how the immune system in the nose responds to respiratory viruses like SARS-CoV-2 in people with weakened immune systems compared to healthy volunteers. Researchers will enroll 40 adults aged 18 to 90, including those who are immunocomp…

This study connects Italian hospitals to a specialized center to find AL amyloidosis earlier in people with related blood conditions. Researchers will screen 760 participants using blood tests and track their health over time. The goal is to speed up diagnosis and learn more abou…

This study looks at how effective vaccines are in people who have received a bone marrow or solid organ transplant. These patients are at high risk for serious infections, but it's not clear how well their weakened immune systems respond to vaccines. Researchers will track 200 tr…

This study is following 300 people with suspected or confirmed systemic vasculitis over 10 years. Researchers are collecting data on symptoms, imaging, and biomarkers to identify who is at higher risk for relapse or poor outcomes. The goal is to better understand the disease and …

This study looks at how the chemotherapy drug treosulfan is processed in the bodies of 70 children (ages 0-18) receiving stem cell transplants for cancer or other blood disorders. Researchers will measure drug levels in the blood to see if adjusting the dose can reduce harmful si…

This study is creating a registry of 600 people with primary cutaneous T-cell lymphoma, a rare type of skin cancer. Researchers will collect past and future medical data to understand how common different forms of the disease are and how long people live with each type. The goal …

This study aims to find the genetic causes of familial pulmonary fibrosis, a lung disease that causes scarring and breathing problems. Researchers will analyze DNA from 126 adults from families where two or more close relatives have the condition. The goal is to identify gene cha…

This study is creating a large European registry of 400 newly diagnosed AL amyloidosis patients. Researchers will collect medical data and blood samples to study the disease using advanced technology. The goal is to improve diagnosis and management of this rare condition, not to …

This study is checking if a new checklist (the Braden QDS scale) can better predict bedsores in newborns in intensive care. About 600 babies under 28 days old and weighing less than 5 kg will be observed. The goal is to see if this tool helps nurses catch pressure injury risks ea…

This study explores how parents of children with blood cancers cope with stress and how their coping style affects their child. Researchers will survey 60 parents and their children (ages 8-17) at multiple hospitals in Italy. The goal is to learn which coping strategies work best…

This study creates a registry of 1500 lung cancer patients to track their health over 10 years. Researchers will collect information on survival, how the disease changes, and how well treatments work in real life. The goal is to learn from patient experiences to improve future ca…

This study looks at oxidative stress—a kind of cellular wear and tear—in people with type 1 diabetes or LADA (a slow-progressing form of autoimmune diabetes). Researchers will collect blood samples from 150 adults to measure stress markers and see how they relate to blood sugar c…

This study looks at the strength and flexibility of the aorta (the main artery) in people with aortic disease who are having heart surgery. Researchers want to find out if certain patient traits are linked to a weaker aortic wall, which could raise the risk of a tear or rupture. …

This study looks at how the immune system reacts to viruses spread by mosquitoes and ticks, like West Nile and Dengue. Researchers will test a new method (ARBOspot) on 500 adults with suspected infections to see if it can detect these viruses more accurately than current tests. T…

This study looks at a new way to grow immune cells (called CTLs) that can recognize and kill pediatric solid tumors like neuroblastoma and sarcoma. Researchers are testing a special bioreactor to produce more of these cells while keeping them effective. The goal is to learn how t…

This study is for people on long-term dialysis who may also have high blood pressure in their lungs (pulmonary hypertension). Researchers want to find out how common this condition is, what causes it, and how it affects patients over time. About 70 adults will get heart ultrasoun…

This study collects medical information from 60 adults diagnosed with either EGPA or HES, two rare conditions that cause high levels of certain white blood cells. Researchers will use artificial intelligence to find patterns that help doctors tell the diseases apart and predict w…

This study looks at 100 patients with acute respiratory failure who are on a breathing machine (ventilator). Researchers want to measure lung instability, which happens when parts of the lung open and close with each breath. They will use a safe, quick test already used in clinic…

This study is creating a personalized immune score to predict severe infections in 150 transplant patients. By measuring immune cells and virus-specific responses before or one month after transplant, researchers aim to identify those at highest risk. The goal is to tailor monito…

This study looks at blood samples from 20 people with advanced liver cancer who are starting immunotherapy. Researchers want to find genetic patterns in immune cells that can tell if a patient will respond well to treatment. The goal is to better understand why some patients bene…

This study follows 600 adults with autoimmune atrophic gastritis, a condition where the immune system attacks the stomach lining, leading to nutrient deficiencies and increased cancer risk. Researchers aim to track how the disease progresses over time and identify factors that le…

This study looks at how well CDK4/6 inhibitors work and what side effects they cause in women aged 70 and older with breast cancer. Researchers will compare these older patients to younger ones to see if age affects treatment outcomes. The goal is to provide better guidance for t…

This study tracks how often blood disorder patients develop serious Aspergillus infections while in the hospital. Researchers will use nasal swabs and air sampling to see if the fungus in the environment leads to infections. About 193 adults admitted to a hematology ward will tak…

This study looks at how sugar molecules attached to proteins might cause or worsen AL amyloidosis, a rare disease where abnormal proteins build up in organs. Researchers will collect blood and bone marrow samples from 100 adults with related conditions to understand this process.…

This study is not testing a new treatment. Instead, it will follow 101 adults with chronic heart failure for up to 10 years to understand how the disease progresses. Researchers will collect health information and check survival rates at 1, 5, and 10 years after diagnosis. The go…

This study uses advanced MRI scans to look at oxygen levels in the lungs of people with early-stage idiopathic pulmonary fibrosis (IPF), a type of lung scarring. The goal is to see if MRI can find areas with low oxygen, which might help doctors identify patients who could benefit…

This study is a large registry that will follow 9,000 adults with lymphoproliferative disorders (a type of blood cancer) for up to 10 years. Researchers will track survival, how well different treatments work, and factors like genetics and overall health that affect outcomes. The…

This study looks at whether the amount of venetoclax in the blood is linked to serious side effects in people with acute myeloid leukemia (AML) who are in remission. Researchers will measure drug levels in 14 patients and track how often severe low white blood cell counts occur. …

This study is creating a large online registry of 1,000 people with ATTR amyloidosis, a rare disease where abnormal proteins build up in organs. Researchers will collect information from diagnosis through follow-up to learn how the disease progresses in real life. The goal is to …

This study looks at how the shingles vaccine (Shingrix) works in people with psoriasis or myelofibrosis who are taking medications that affect the immune system. Researchers will compare the immune response in 150 participants—some on these therapies and some not—to see if the va…

This study gathers information from 418 patients diagnosed with endocarditis, a serious heart infection. The goal is to better understand the disease and identify factors that lead to worse outcomes. No new treatments are being tested; instead, researchers will review medical rec…

This study aims to better understand how common enterovirus infections are in newborns in Italy, especially a dangerous type called Echovirus 11. Researchers will analyze samples from up to 1,600 babies in intensive care to track the virus and identify risk factors for severe ill…

This study looks for genetic causes of out-of-hospital cardiac arrest in people aged 18-50 in Lombardy, Italy. Researchers will analyze blood samples from 1,725 patients to find inherited heart disease genes. They will also check family members to help prevent future sudden cardi…

This study is building a large registry of 5000 people with AL amyloidosis, a rare disease where abnormal proteins build up in organs. Researchers will collect information from medical records and follow-ups to learn how the disease progresses and how current treatments affect it…

This study looks at whether patients who have head and neck reconstructive surgery with a free flap (tissue moved from another body part) recover just as well on a regular hospital ward as in the intensive care unit (ICU). About 192 adults having this surgery will be randomly ass…

This study looks at 100 adults with inactive liver cysts caused by a parasite. Researchers want to see if a blood test (immunoblotting) shows different patterns between people who received treatment and those who did not. The goal is to better understand how the body responds to …

This study tests whether advanced MRI scans can identify different immune environments inside lung tumors. Currently, this information requires a tissue biopsy. If successful, MRI could provide a non-invasive way to understand the tumor's immune status. The study will enroll 50 a…

This study looks for inherited gene changes that might make some people more likely to develop myeloproliferative neoplasms (MPN), a group of rare blood cancers. Researchers will study 313 patients who were diagnosed young or have a family history of blood cancers. The goal is to…

This study aims to understand why some children still have adenoid tissue after surgery, causing symptoms to return. Researchers will look at 1,200 children to see if factors like age, sex, weight, and palate length affect how completely the adenoids are removed. The goal is to i…

This study follows 150 pregnant women infected with parvovirus B19 to see how often the virus passes to the fetus and what complications may arise. Researchers will track pregnancy outcomes, newborn health, and long-term effects. The goal is to better understand risks and improve…