Fondazione Irccs Policlinico San Matteo Di Pavia

This study looks at a non-surgical procedure called renal embolization to shrink enlarged kidneys in 30 dialysis patients with autosomal dominant polycystic kidney disease (ADPKD). The goal is to reduce kidney size enough to make a future kidney transplant possible and improve co…

This study compares two food supplements, Cynacol and Metacol, to see which one lowers 'bad' LDL cholesterol better in people with mild high cholesterol. About 40 adults aged 35-70 with LDL levels between 115-190 mg/dL will take one supplement daily for 90 days. The goal is to fi…

This study is testing whether a supplement called Euglycem, when taken with a standard healthy diet, can lower blood sugar levels in people with dysglycemia (abnormal blood sugar). About 108 adults with a BMI of 30 or less will be split into two groups: one gets Euglycem plus die…

This study tests whether starting a heart-lung machine (ECMO) at the scene of a cardiac arrest, instead of waiting until arrival at the hospital, can improve survival and brain function. Researchers will enroll 20 adults aged 18-70 who suffer a cardiac arrest that does not respon…

This study is testing a new blood test called ARBOspot that looks for immune cell responses to viruses spread by mosquitoes and ticks. Researchers will enroll 500 adults in Italy with suspected arbovirus infection. The goal is to see if this test can help diagnose infections that…

This study will check if a bedside examination done by emergency room doctors can accurately predict whether vertigo, dizziness, or unsteadiness is caused by a brain problem like a stroke. Researchers will study 825 adults in the ER and compare the exam's results to standard test…

This study aims to see if a new PCR-based test can diagnose malaria, leishmania, and pneumocystis infections faster and more accurately than current methods. Researchers will analyze about 200 stored samples from patients. The goal is to improve diagnosis and species identificati…

This study looks at how well the shingles vaccine works in people with weakened immune systems, such as those with cancer or autoimmune diseases. Researchers will measure immune responses and track side effects in 300 adults. The goal is to see if the vaccine can effectively prev…

This study follows 200 adults and children with eosinophilic esophagitis (EoE) in Italy to learn how the disease progresses over time and how well current treatments work. EoE is an allergic condition that causes swallowing problems and can lead to scarring if not treated. The re…

This study is a registry that collects medical information from 1,000 COVID-19 patients treated at San Matteo Hospital in Italy. Researchers will analyze the data to find patterns linked to death during hospitalization. No new drug or treatment is being tested; the goal is to lea…

This study is a registry that collects information from routine care to see how well minimally invasive heart valve procedures work over 5 years. It includes adults over 18 who have had a transcatheter aortic valve replacement or similar treatment. No new treatments are given; th…

This study will follow 300 people with suspected or confirmed systemic vasculitis for up to 10 years. Researchers will collect medical data, images, and blood samples to identify factors that predict relapses, complications, and death. The goal is to better understand the disease…

This study follows 200 adults with rheumatoid arthritis who are already in stable remission from standard medications. Researchers will track their health over up to 5 years using exams, ultrasound, and X-rays to see who stays well and who has a flare. The goal is to learn how to…

This study looks at a specific gene (IGLV1-44) to understand why it causes two different diseases: AL amyloidosis and POEMS syndrome. Researchers will analyze blood and bone marrow samples from 100 adults with these conditions or multiple myeloma. The goal is to find genetic patt…

This study is tracking 70 adults on long-term dialysis to find out how often they develop high blood pressure in the lungs (pulmonary hypertension) and what causes it. Participants get heart ultrasounds and, if needed, more tests to confirm the condition. Researchers will follow …

This study aims to find genetic causes of out-of-hospital cardiac arrest in people aged 18–50 in Lombardy, Italy. Researchers will analyze blood samples from 1,725 patients and also check family members for inherited heart risks. The goal is to better understand why cardiac arres…

This study looks at how the chemotherapy drug treosulfan is processed in children getting a stem cell transplant. The goal is to find the right dose for each child to reduce side effects and improve outcomes. Researchers will measure drug levels in the blood and track how patient…

This study looks at how parents of children with cancer cope with stress and how that affects their child's emotional well-being. Researchers will survey 60 parents and their children (ages 8–17) being treated at pediatric cancer centers in Italy. The goal is to understand which …

This study looks at how the Shingrix vaccine (for shingles) works in people with psoriasis or myelofibrosis who are taking drugs that weaken their immune system. Researchers will compare their immune response to that of similar patients not on these drugs. The goal is to understa…

This study is building a large registry of 5,000 people with AL amyloidosis, a rare disease where abnormal proteins build up in organs. Researchers will collect real-world data on how the disease progresses and how current treatments affect it. No new drug is being tested; the go…

This study is creating a large European registry of 400 newly diagnosed AL amyloidosis patients. Researchers will collect medical data and blood samples to study the disease using advanced technology. The goal is to better understand how AL amyloidosis develops and progresses, wh…

This study is creating a network of hospitals in Italy to find and treat AL amyloidosis earlier. Researchers will screen people with certain blood conditions (MGUS or smoldering myeloma) using special tests. The goal is to speed up diagnosis, connect patients to the right care, a…

This study is a large registry that will follow 9,000 adults with lymphoproliferative disorders (a type of blood cancer) for up to 10 years. Researchers aim to learn how long people live, how different treatments work, and what factors affect the disease. No new treatments are gi…

This observational study will measure oxidative stress and antioxidant levels in 75 people with type 1 diabetes and 75 with LADA (a slow-progressing form of autoimmune diabetes). Researchers will collect blood samples and compare markers like d-ROMs, BAP, and HbA1c to see if oxid…

This study is creating a large database of 1,000 people with ATTR amyloidosis, a rare disease that causes abnormal protein buildup in organs. Researchers will collect health information over time to better understand how the disease progresses and to develop tools that help docto…

This study is tracking enterovirus infections in newborns across Italy, with a special focus on a dangerous strain called Echovirus 11. Researchers will analyze samples from 1,600 babies in intensive care to understand how common these infections are, what makes some cases severe…

This study looks at why some children still have adenoid tissue after surgery, causing symptoms to return. Researchers will examine 1,200 children to see if factors like age, sex, weight, and palate length affect how completely the adenoids are removed. The goal is to understand …

This study looks at how well hip, knee, shoulder, and other joint replacement surgeries work in adults with inherited bleeding disorders like hemophilia. Researchers will collect information from medical records and follow patients over time to understand risks, complications, an…

This study will use advanced MRI techniques to measure oxygen levels in the lungs of 50 people with early-stage idiopathic pulmonary fibrosis (IPF). The goal is to see if MRI can identify areas of low oxygen, which may be linked to disease progression. This is an observational st…

This study tests whether advanced MRI scans can identify different immune types of non-small cell lung cancer (NSCLC) without needing a tissue biopsy. Researchers will scan 50 adults with early-stage lung cancer and compare MRI results to standard lab tests. If successful, this a…

This study is looking for immune system markers that might predict whether a pregnant woman with a first-time HCMV infection will pass the virus to her unborn baby. Researchers will study blood samples from 90 pregnant women and their newborns to see which immune responses are li…

This study looks at how effective vaccines are in preventing serious infections in people who have received a bone marrow or solid organ transplant. Researchers will check the immune system's ability to respond to vaccines and track infections over five years. The goal is to impr…

This study aims to develop a better method for extracting stem cells from umbilical cord blood. Researchers will compare the standard technique with a new approach that uses a special liquid to separate stem cells gently, and also test if ozone treatment can help the cells grow. …

This study investigates how a sugar modification called N-glycosylation affects AL amyloidosis, a rare disease where abnormal proteins build up in organs. Researchers will analyze blood and bone marrow samples from 100 adults with related conditions to better understand the disea…

This study looks at how a common fungus called Aspergillus spreads in hospital wards and affects blood cancer patients. Researchers will take nasal swabs from 193 adults when they enter and leave the hospital, and also test the air in the ward. The goal is to find links between f…

This study is testing whether a risk assessment scale called the Braden QDS can accurately predict pressure injuries (bedsores) in newborns admitted to the Neonatal Intensive Care Unit (NICU). Researchers will enroll 600 newborns under 28 days old and weighing less than 5 kg. The…

This observational study aims to better understand the mechanical properties of the aortic wall in patients with aortic aneurysms or dissection. Researchers will measure tissue strength from samples taken during surgery and compare them to samples from patients without aortic dis…

This study looks at how older women (70 years and above) with breast cancer handle CDK4/6 inhibitors, a common targeted therapy. Researchers will track side effects and compare them to younger patients. The goal is to gather real-world data to improve treatment decisions for this…

This study follows 600 adults with autoimmune atrophic gastritis, a condition where the immune system attacks the stomach lining, leading to nutrient deficiencies and increased cancer risk. Researchers aim to track how the disease progresses over time and identify factors that le…

This study is developing a personalized immune score to predict severe infections in people with weakened immune systems, such as transplant recipients. Researchers will measure different immune cells and virus-specific responses in 150 adult and pediatric patients before or one …

This study is a registry that collects information from 520 patients diagnosed with central nervous system (CNS) infections, such as meningitis or encephalitis. Researchers will track how many patients survive to discharge. The goal is to better understand these rare but serious …

This study gathers information from 418 patients diagnosed with endocarditis, a serious heart infection. Researchers want to understand what factors lead to worse outcomes. No new treatments are tested—the goal is simply to learn from past and current patient experiences.

This study looks at 100 adults with inactive liver cysts caused by a parasite. Researchers compare immune system markers between people who received treatment and those who did not. The goal is to learn how the body responds over time, not to test a new treatment.

This study follows 150 pregnant women infected with parvovirus B19 to see how often the virus passes to the fetus and what complications may occur. Researchers will track pregnancy outcomes, newborn health, and long-term effects. No treatments are tested; the goal is to better un…

This study creates a registry of 1500 lung cancer patients to track their health over 10 years. Researchers will collect information on survival, how the disease changes, and how well treatments work in real life. The goal is to learn more about lung cancer to improve future care…

This study looks at whether holding a deep breath during breast cancer radiation therapy can lower the amount of radiation reaching the heart. Researchers will compare heart radiation doses in 400 women who use a special breathing device versus those who breathe normally. The goa…

This study is creating a registry of 101 adults with chronic heart failure to track their health over time. Researchers will collect data on disease progression and survival at one, five, and ten years after diagnosis. The goal is to better understand how heart failure evolves, n…

This observational study will compare nasal immune responses to respiratory viruses like SARS-CoV-2 in 40 adults, including immunocompromised patients and healthy volunteers. Researchers aim to understand how underlying conditions and treatments affect immune cell activity in the…

This study looks at whether patients who have head and neck reconstructive surgery with a tissue flap recover just as well on a regular hospital ward as in the intensive care unit (ICU). About 192 adults will be randomly assigned to either the ICU or a specialty ear-nose-throat w…

This study looks at blood samples from 20 people with advanced liver cancer who are starting immunotherapy. Researchers want to find genetic clues in immune cells that can tell if a patient will respond well to treatment. The goal is to better understand why some patients benefit…

This study collects medical data from 60 adults diagnosed with either EGPA or HES, two rare conditions that cause high levels of a type of white blood cell. Researchers will use artificial intelligence to find patterns that help doctors tell the diseases apart and predict how pat…

This study looks at 100 patients with acute respiratory failure who are on a breathing machine (ventilator). Researchers want to measure lung instability, which happens when parts of the lung open and close with each breath. They will use a safe, quick method to analyze data from…

This study looks at whether special imaging tests can help predict a serious lung condition called bronchopulmonary dysplasia (BPD) in premature babies. Researchers will use electrical impedance tomography (EIT) and lung ultrasound to check how air moves in the lungs of 104 prete…

This study looks at how much venetoclax is in the blood of people with acute myeloid leukemia (AML) who are in remission and still receiving treatment. The goal is to see if higher drug levels are linked to more severe side effects, like low white blood cell counts. By understand…

This study aims to uncover the genetic causes of familial pulmonary fibrosis, a progressive lung disease that runs in families. Researchers will analyze DNA from 126 adults with a family history of the condition, looking for gene changes linked to lung scarring. The goal is to im…

This study aims to improve how immune cells (called CTLs) are grown in the lab so they can better recognize and kill pediatric solid tumors like neuroblastoma and osteosarcoma. Researchers are using a special device called a G-Rex bioreactor to produce larger numbers of these cel…

This study aims to uncover inherited (germline) genetic factors that make some people more likely to develop myeloproliferative neoplasms (MPNs), a group of blood cancers. Researchers will analyze DNA from 313 patients diagnosed at a young age or with a family history of blood ca…

This Italian study is collecting real-world data from 300 patients with advanced non-small cell lung cancer who are receiving a combination of nivolumab, ipilimumab, and chemotherapy as their first treatment. The goal is to see how long patients live and how long the cancer stays…

This study follows 200 women having surgery for symptomatic uterine fibroids to see how their pelvic floor changes over a year. Half will have a hysterectomy, half a myomectomy. Researchers will measure pelvic floor structure and symptoms at 1, 6, and 12 months after surgery. The…

This study looks at whether a heart protein called BNP, measured in infancy and again in adolescence, can help identify teens at risk for metabolic syndrome—a cluster of conditions like obesity, high blood pressure, and diabetes. Researchers are following 70 teens who were part o…

This study is a registry that will collect information from about 600 people with primary cutaneous T-cell lymphoma, a rare type of skin cancer. Researchers will look back at past cases and follow new ones to understand how common different forms of the disease are and how long p…