Fondazione Irccs Policlinico San Matteo Di Pavia

This study tested a new way to deliver the drug everolimus directly to the lungs using tiny particles called liposomes. The goal was to treat chronic lung rejection (bronchiolitis obliterans syndrome) after a lung transplant. Researchers used human lung tissue and cells in the la…

This study tested whether special software on standard ultrasound machines can accurately measure liver fat in people with non-alcoholic fatty liver disease (NAFLD). Researchers compared the ultrasound results to the Fibroscan CAP method in 25 adults. The goal was to see if the u…

This study looked at whether a medicine called Evusheld can prevent COVID-19 in people with weakened immune systems who did not get protection from vaccines. The study included 88 adults who were at high risk. Researchers tracked how many got sick with COVID-19 symptoms to see if…

This study looked at whether a supplement called citicoline can improve vision in people with glaucoma after they have eye surgery. Six adults took either citicoline or a placebo for a short time. The goal was to see if citicoline could help protect the optic nerve and improve vi…

This study investigates inherited thrombocytopenias, rare conditions where low platelet counts cause bleeding problems. About half of patients have an unknown genetic cause. Researchers aim to identify new disease genes and build a lab-grown bone marrow model to test how well dru…

This completed study tested different ways to use an ultrasound machine to measure liver fat in 35 healthy adults. The goal was to find the most reliable technique for non-invasively diagnosing fatty liver disease, a common condition linked to obesity and diabetes. By standardizi…

This study looked back at medical records of 100 adults with multiple myeloma that had returned after initial treatment. Researchers compared how long patients stayed cancer-free on four different three-drug combinations. The goal was to see which combination worked best in real-…

This completed study looked at blood vessel cells from 30 people with primary myelofibrosis, a rare bone marrow disorder. Researchers wanted to see if these cells act like stem cells that could be the origin of the disease. By growing the cells in the lab, they aimed to understan…

This completed study involved 250 adults with AL amyloidosis, a rare disease where abnormal proteins damage organs. Researchers analyzed patient samples and data to find biological markers that predict how well someone will respond to initial treatments. The goal is to help docto…

This study used computer simulations to compare three types of radiation (photons, protons, and carbon ions) for treating a dangerous heart rhythm called ventricular tachycardia. Researchers created treatment plans for 23 patients who were already scheduled for standard catheter …

This study looked at 30 people newly diagnosed with cardiac AL amyloidosis, a rare disease where abnormal proteins damage the heart. Researchers used advanced MRI, echocardiogram, and PET scans to see if these images could predict survival and show how well chemotherapy works. Th…

This study looked at whether counting a specific type of cell in the blood (circulating endothelial cells) can predict the risk of acute graft-versus-host disease (GVHD) in adults receiving a stem cell transplant for blood cancer. Researchers measured these cells before transplan…

This study looked at compassion fatigue—a mix of burnout and stress from caring for others—in 159 healthcare workers in emergency rooms and intensive care units. Workers filled out a questionnaire before and after taking part in focus groups designed to help them cope. The goal w…

This study created a detailed database of 60 heart transplant patients to learn why they die, get sick, or need hospital care. Researchers collected information over time to identify the main causes of death and illness after a heart transplant. The goal was to better understand …

This completed study looked at bone marrow stem cells from 70 adults with acute myeloid leukemia (AML) who had a favorable genetic marker (NPM1 mutation). The goal was to understand why more than half of these patients still relapse despite having a good prognosis. Researchers an…

This study looked at 80 teenagers aged 14 to 17 who were already experiencing emotional or relationship distress. Researchers used a questionnaire to measure anxiety and other psychological struggles. For those with high distress, the study also tested a short program of 10 couns…

This completed study looked at whether a regional guideline for managing sepsis (a severe infection) in pregnant and postpartum women improved outcomes. Researchers compared 52 women treated before and after the guideline was introduced in Lombardy, Italy. They measured hospital …

This study looked at 70 people—some with primary myelofibrosis and some healthy—to understand how certain immune cells called MDSCs fuel inflammation in this rare bone marrow disease. Researchers also checked how these cells change with treatment and whether they help form new bl…

This study looked at different ultrasound techniques to measure liver stiffness in 72 adults with chronic liver disease. The goal was to see how newer methods compare to an established one. No treatments or interventions were given; it was purely a comparison of measurement tools…

This study looked at how the antifungal drug posaconazole affects blood levels of the cancer drug venetoclax in 15 adults with acute myeloid leukemia (AML) who were also receiving a hypomethylating agent (azacitidine or decitabine). The goal was to see how many patients reached s…

This completed study looked at how well early COVID-19 antiviral therapies work in cancer patients. Researchers tracked 112 patients with solid tumors who received these treatments to see how many needed hospitalization within 14 days. The goal is to fill knowledge gaps and impro…

This completed study tracked 581 hospitalized children aged 1-16 to see how antibiotic treatment affects the development of MRSA in the nose. Researchers compared children who received antibiotics to those who did not. The goal is to understand how antibiotic use drives antimicro…

This study looked at 445 patients with mild acute biliary pancreatitis to compare having gallbladder removal surgery during the same hospital stay versus waiting for a later date. The goal was to see which approach leads to fewer repeat hospital visits for gallstone-related probl…